| Weight | 266.34 g/mol |
|---|---|
| Formula | C18H18O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Honokiol (35354-74-6)
Score:
#1949 in Biochemistry
,
#4129 in Biology
,
#5208 in Chemistry
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- Sigma-Aldrich - Honokiol128.00 - 258.50 USD
- Fisher Scientific - Search for Honokiol
- TCI - Honokiol79.00 - 265.00 USD
- Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo (Journal of Biological Chemistry, 2003)
- Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation (Biochemical Pharmacology, 1994)
- In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. (European Journal of Pharmacology, 2004)
- The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells (Blood, 2005)
- Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent (Antioxidants & Redox Signaling, 2009)
- Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis (Blood, 2005)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
-
InChIKeyFVYXIJYOAGAUQK-UHFFFAOYSA-N
- Pubchem - Honokiol
- Wikipedia - honokiol
Honokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia. It has been identified as one the chemical compounds in some traditional eastern herbal medicines along with magnolol, 4-O-methylhonokiol, and obovatol.
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Synthesis
Reactant
+
2-Allyl-4-chlorophenol
(Decarboxylative coupling)
2-ALLYL-4-BROMOPHENOL
+
Reactant
(Stille)
Reactant
+
1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide
(Nicolaou IBX dehydrogenation)
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Honokiol
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