| Weight | 408.545 g/mol |
|---|---|
| Formula | C19H24N2O4S2 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
Omapatrilat (167305-00-2)
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- Sigma-Aldrich - Omapatrilat79.00 - 319.00 USD
- Fisher Scientific - Search for Omapatrilat
- TCI - Search for Omapatrilat
- Comparison of Omapatrilat and Enalapril in Patients With Chronic Heart Failure The Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE) (Circulation, 2002)
- Omapatrilat and enalapril in patients with hypertension: The Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial (American Journal of Hypertension, 2004)
- Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial (The Lancet, 2000)
- Omapatrilat Reduces Pulse Pressure and Proximal Aortic Stiffness in Patients With Systolic Hypertension Results of the Conduit Hemodynamics of Omapatrilat International Research Study (Circulation, 2002)
- Omapatrilat Reduces Pulse Pressure and Proximal Aortic Stiffness in Patients With Systolic Hypertension (Circulation, 2002)
- Effects of omapatrilat in low, normal, and high renin experimental hypertension (American Journal of Hypertension, 1998)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CC(N2C(C1)SCCC(C2=O)NC(=O)C(CC3=CC=CC=C3)S)C(=O)O
-
InChIKeyLVRLSYPNFFBYCZ-UHFFFAOYSA-N
- Pubchem - Omapatrilat
- Wikipedia - omapatrilat
Omapatrilat (INN, proposed trade name Vanlev) is an experimental antihypertensive agent that was never marketed. It inhibits both neprilysin (neutral endopeptidase, NEP) and angiotensin-converting enzyme (ACE). NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling.
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Omapatrilat
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