| Weight | 203.669 g/mol |
|---|---|
| Formula | C9H14ClNO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
PHENYLEPHRINE HYDROCHLORIDE (61-76-7)
Phenylephrine · Neosynephrine · Phenylephrine Tannate
Score:
#201 in Neuroscience
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#246 in Biochemistry
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#936 in Biology
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#1035 in Chemistry
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- Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial KATP Channels (Circulation Research, 2001)
- Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Proteincoupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy? (Journal of Cell Biology, 1998)
- A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. (Anesthesia & Analgesia, 2002)
- Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes. (Journal of Biological Chemistry, 1989)
- Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. (Journal of Biological Chemistry, 1994)
- Fetal and Maternal Effects of Phenylephrine and Ephedrine during Spinal Anesthesia for Cesarean Delivery (Anesthesiology, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Phenylephrine
- Neosynephrine
- Phenylephrine Tannate
- Neo Synephrine
- Metasympatol
- Mezaton
- (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol
- Metaoxedrin
- Neo-Synephrine
-
SMILESCNCC(C1=CC(=CC=C1)O)O.Cl
-
InChIKeyOCYSGIYOVXAGKQ-UHFFFAOYSA-N
- Pubchem - PHENYLEPHRINE HYDROCHLORIDE
- Wikipedia - phenylephrine hydrochloride
Phenylephrine is a selective 1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is marketed as an alternative for the decongestant pseudoephedrine, although clinical trials show phenylephrine, taken orally at the recommended dose, to be no more effective than placebo for allergy relief. Phenylephrine can also cause a decrease in heart rate through reflex bradycardia.
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Synthesis
Reactant
+
3-Chlorophenol
(Grignard alcohol)
Methylboronic acid
+
Reactant
(Chan-Lam coupling reaction)
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PHENYLEPHRINE HYDROCHLORIDE
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