| Weight | 381.259 g/mol |
|---|---|
| Formula | C18H18Cl2N2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Piclamilast (144035-83-6)
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- Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]-piclamilast and [3H]-rolipram (Journal of Pharmacology and Experimental Therapeutics, 2003)
- Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells: Cross-talk between the cAMP and the retinoic acid signaling pathways (Journal of Biological Chemistry, 2004)
- Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H2O2 via mechanisms involving AP-1 activation (Free Radical Research, 2012)
- Selective inhibition of purified human phosphodiesterase 4A expressed in yeast cell GL62 by ciclamilast, piclamilast, and rolipram (Acta Pharmacologica Sinica, 2004)
- Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients. (Lung, 2004)
- Comparison of piclamilast with ciclamilast in bronchodilating and antiallergic effects (Journal of Zhejiang University. Medical sciences, 2003)
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SMILESCOC1=C(C=C(C=C1)C(=O)NC2=C(C=NC=C2Cl)Cl)OC3CCCC3
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- Pubchem - Piclamilast
- Wikipedia - piclamilast
Piclamilast (RP 73401), is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma.
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