| Weight | 323.805 g/mol |
|---|---|
| Formula | C14H14ClN3O2S |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Pirinixic acid (50892-23-4)
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- Sigma-Aldrich - Pirinixic acid44.10 - 140.50 USD
- Fisher Scientific - Search for Pirinixic acid
- TCI - Pirinixic acid192.00 - 651.00 USD
- Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. (Journal of Medicinal Chemistry, 2008)
- Aminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E2 Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo (Journal of Medicinal Chemistry, 2013)
- Alkyl Substituted Pirinixic Acid Derivatives as Potent Dual Agonists of the Peroxisome Proliferator Activated Receptor Alpha and Gamma (Archiv Der Pharmazie, 2008)
- Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. (Journal of Medicinal Chemistry, 2008)
- Quinoline-Based Derivatives of Pirinixic Acid as Dual PPAR / Agonists (Archiv Der Pharmazie, 2007)
- Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers. (Journal of Chromatography A, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C
-
InChIKeySZRPDCCEHVWOJX-UHFFFAOYSA-N
- Pubchem - Pirinixic acid
- Wikipedia - pirinixic acid
Pirinixic acid is a peroxisome proliferator-activated receptor alpha (PPAR) agonist that is under experimental investigation for prevention of severe cardiac dysfunction, cardiomyopathy and heart failure as a result of lipid accumulation within cardiac myocytes. Treatment is primarily aimed at individuals with an adipose triglyceride lipase (ATGL) enzyme deficiency or mutation because of the essential PPAR protein interactions with free fatty acid monomers derived from the ATGL catalyzed lipid oxidation reaction. It was discovered as WY-14,643 in 1974.
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