Probenecid (57-66-9)

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  50 mg
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  5 g
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  25 g
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  50 g
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  50 g
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  100 g
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  100 g
  $232.00

Most-cited Publications

• Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. (Drug Metabolism and Disposition, 2004)
• Cerebrospinal Fluid Amine Metabolites in Affective Illness: The Probenecid Technique (American Journal of Psychiatry, 1973)
• Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment (Neuroscience, 2001)
• 5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid. (Nature, 1970)
• Probenecid, a gout remedy, inhibits pannexin 1 channels. (American Journal of Physiology-cell Physiology, 2008)
• Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives (Antimicrobial Agents and Chemotherapy, 1974)

Areas of Application

Safety

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Trends

Alternate Names

• Benemid
• Benuryl
• Probenecid Weimer
• Benecid
• Probecid
• Pro-Cid
• SMILES
  CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
• InChIKey
  DBABZHXKTCFAPX-UHFFFAOYSA-N

Estimated Properties

External Links

• Pubchem - Probenecid
• Wikipedia - probenecid
  Probenecid, also sold under the brandname Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia. Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.

Synthesis

4-(Chlorosulfonyl)benzoic acid  +  DIPROPYLAMINE (Sulfonamide)

Propylboronic acid  +  4-[(propylamino)sulfonyl]benzoic acid (Chan-Lam coupling reaction)

Synthesis of Probenecid ›

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Probenecid

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