procaine (59-46-1)

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Suppliers

• Sigma-Aldrich - Search for procaine
• Fisher Scientific - Search for procaine
• TCI - Search for procaine

Most-cited Publications

• Differences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions (The Journal of General Physiology, 1966)
• A CONTROLLED STUDY OF CAUDAL EPIDURAL INJECTIONS OF TRIAMCINOLONE PLUS PROCAINE FOR THE MANAGEMENT OF INTRACTABLE SCIATICA (Spine, 1991)
• Effect of procaine on electrical properties of squid axon membrane. (American Journal of Physiology, 1959)
• Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells (Cancer Research, 2003)
• PAIN AND DISABILITY OF THE SHOULDER AND ARM: TREATMENT BY INTRAMUSCULAR INFILTRATION WITH PROCAINE HYDROCHLORIDE (JAMA, 1942)
• Anterior Paralimbic Mediation of Procaine-Induced Emotional and Psychosensory Experiences (Archives of General Psychiatry, 1997)

Areas of Application

Safety

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Trends

Alternate Names

• Novocain
• Novocaine
• Procaine Hydrochloride
• Anuject
• Procaina Serra
• Hewedolor-Procain
• Prcaine chlorhydrate Lavoisier
• procain-loges
• Gerokit
• Procain curasan
• Rwo Procain
• Procain Steigerwald
• Geriocaine
• Procain Rdler
• Procain Jenapharm
• Procain Braun
• Lophakomp-Procain N
• SMILES
  CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
• InChIKey
  MFDFERRIHVXMIY-UHFFFAOYSA-N

External Links

• Pubchem - procaine
• Wikipedia - procaine
  Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions, procaine is referred to generically as novocaine.

Synthesis

4-aminobenzoic acid  +  2-Chlorotriethylamine (Ester from carboxilic acid(SN2))

Ethylboronic acid  +  Reactant (Chan-Lam coupling reaction)

Reactant  +  dimethyl sulfide (Corey-Kim oxidation of secondary alcohols)

Synthesis of procaine ›

Similar Compounds

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Tetracaine hydrochloride (136-47-0, 53762-93-9)

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isopropyl 4-aminobenzoate (18144-43-9)

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tert-Butyl 4-aminobenzoate (18144-47-3)

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ethyl 4-(methylamino)benzoate (10541-82-9)

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ethyl 4-hydrazinylbenzoate (14685-90-6)

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Ethyl 4-dimethylaminobenzoate (10287-53-3)

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pentyl 4-aminobenzoate (13110-37-7)

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ethyl 3,4-diaminobenzoate (37466-90-3)

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heptyl 4-aminobenzoate (14309-40-1)

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methyl 4-(methylamino)benzoate (18358-63-9)

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ethyl 4-amino-3-bromobenzoate (7149-03-3)

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isopropyl 3-aminobenzoate (35005-25-5)

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cyclopentyl 4-aminobenzoate (37005-75-7)

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4-Methoxycarbonylphenyl isothiocyanate (3662-78-0)

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ethyl 4-amino-3-chlorobenzoate (82765-44-4)

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ethyl 4-[(chloroacetyl)amino]benzoate (26226-72-2)

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4-(ethoxycarbonyl)benzoic acid (713-57-5)

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886-86-2 (886-86-2)

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ethyl 3-hydrazinobenzoate hydrochloride (940875-99-0)

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tert-butyl 4-nitrobenzoate (19756-72-0)

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2-Hydroxyethyl benzoate (94-33-7)

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ethyl 3-amino-4-(ethylamino)benzoate (202131-30-4)

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ethyl 4-(aminomethyl)benzoate (366-84-7)

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Ethyl 4-(Chloromethyl)benzoate (1201-90-7)

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Isopropyl 2-aminobenzoate (18189-02-1)

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3-Ethoxycarbonylphenyl isothiocyanate (3137-84-6)

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4-Morpholinobenzoic acid (7470-38-4)

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ethyl 4-amino-3,5-diiodobenzoate (5400-81-7)

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ethyl 4-[(trifluoroacetyl)amino]benzoate (24568-14-7)

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Ethyl 3,5-dimethylbenzoate (21239-29-2)

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methyl 4-(1-piperazinyl)benzoate hydrochloride (1269393-85-2)

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Ethyl 4-fluorobenzoate (451-46-7)

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4631-69-0 (4631-69-0)

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BUTYL BENZOATE (136-60-7)

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ISOBUTYL ANTHRANILATE (7779-77-3)

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Ethyl 4-chlorobenzoate (7335-27-5)

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ethyl 4-(acetoacetylamino)benzoate (30764-23-9)

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Ethyl 2-naphthoate (3007-91-8)

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BUTYL ANTHRANILATE (7756-96-9)

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triethyl benzene-1,3,5-tricarboxylate (4105-92-4)

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Ethyl 4-acetylbenzoate (38430-55-6)

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Ethyl 2-(methylamino)benzoate (35472-56-1)

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procaine

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