prothionamide (14222-60-7)

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Suppliers

• Sigma-Aldrich - prothionamide
  60.00 - 333.50 USD
• Fisher Scientific - Search for prothionamide
• TCI - prothionamide
  73.00 - 225.00 USD

Most-cited Publications

• A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man (Journal of Antimicrobial Chemotherapy, 1984)
• High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids (Journal of Chromatography B: Biomedical Sciences and Applications, 1981)
• Plasma levels of ethionamide and prothionamide in a volunteer following intravenous and oral dosages (Leprosy Review, 1987)
• A CLINICAL TRIAL OF ETHIONAMIDE AND PROTHIONAMIDE FOR TREATMENT OF LEPROMATOUS LEPROSY (American Journal of Tropical Medicine and Hygiene, 2006)
• A study of acute intolerance to ethionamide, including a comparison with prothionamide, and of the influence of a vitamin B-complex additive in prophylaxis. (Tubercle, 1969)
• A review of the use of ethionamide and prothionamide in childhood tuberculosis (Tuberculosis, 2016)

Safety

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Trends

Alternate Names

• Peteha
• Fatol Brand of Prothionamide
• Wernigerode Brand of Prothionamide
• Sanavita Brand of Prothionamide
• Protionamide
• ektebin
• SMILES
  CCCC1=NC=CC(=C1)C(=S)N
• InChIKey
  VRDIULHPQTYCLN-UHFFFAOYSA-N

External Links

• Pubchem - prothionamide
• Wikipedia - protionamide
  Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis. It has also been tested for use in the treatment of leprosy.

Synthesis

Acetic Acid  +  Pyridine (Minisci reaction)

Thioisonicotinamide  +  1-CHLOROPROPANE (Friedel-Crafts alkylation)

Synthesis of prothionamide ›

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1-(4-methylpyridin-2-yl)acetone (42508-80-5)

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2-PROPYLISONICOTINIC ACID (57663-82-8)

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[1-(5-methyl-2-pyridinyl)propyl]amine dihydrochloride (1269384-23-7)

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(1-methyl-2-pyridin-2-ylethyl)amine (51038-40-5)

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2-methylpyridine-4-carboxamide (19354-04-2)

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N-methyl-1-pyridin-2-ylpropan-2-amine (55496-56-5)

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1-(6-methylpyridin-2-yl)acetone (65702-08-1)

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2-acetyl-4-isopropylpyridine (142896-09-1)

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70715-17-2 (70715-17-2)

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(4-methylpyridin-2-yl)methanamine (129768-95-2)

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1-(5-methylpyridin-2-yl)acetone (73010-36-3)

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2-Propionylpyridine (3238-55-9)

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2739-74-4 (2739-74-4)

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1-(3-methyl-2-pyridinyl)-1-propanamine (1015846-40-8)

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2-cyclopropylquinoline-4-carbohydrazide (119778-68-6)

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1-(3-Methylpyridin-2-yl)acetone (39050-03-8)

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2-ETHYL-6-METHYLPYRIDINE (1122-69-6)

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2-Pyridylacetonitrile (2739-97-1)

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1-(3-METHYLPYRIDIN-2-YL)PROPAN-2-AMINE (91054-51-2)

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2-BUTYRYLPYRIDINE (22971-32-0)

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1-(6-methyl-2-pyridinyl)ethanamine (58088-67-8)

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7137-97-5 (7137-97-5)

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2,6-Diethylpyridine (935-28-4)

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2-(2-Aminoethyl)pyridine (2706-56-1)

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59576-30-6 (59576-30-6)

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Betahistine dihydrochloride (5579-84-0)

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Pentyl 2-pyridyl ketone (42203-03-2)

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1-Cyclopropyl-1-(6-methyl-2-pyridinyl)methanamine dihydrochloride (1255717-35-1)

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4-(chloromethyl)-2-methylpyridine hydrochloride (847610-87-1)

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6-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride (108989-52-2)

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T-BUTYL 2-PYRIDYL KETONE (31595-32-1)

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6952-53-0 (6952-53-0)

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2,4,6-Trimethylpyridine (108-75-8, 29611-84-5)

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6304-27-4 (6304-27-4)

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25877-30-9 (25877-30-9)

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2-(1-Cyclohexen-1-yl)pyridine (14159-55-8)

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2-(2-Propoxyethyl)pyridine (70644-45-0)

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2-(2-Isopropoxyethyl)pyridine (70715-19-4)

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2-(2-piperidin-2-ylethyl)pyridine (6312-04-5)

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Sodium 2-(pyridin-2-yl)acetate (67870-16-0)

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2-(pyridin-2-yl)acetic acid (13115-43-0, 54363-97-2)

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2-Pyridylacetic acid hydrochloride (16179-97-8)

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[2-methoxy-1-(2-pyridinyl)ethyl]amine dihydrochloride (1269394-08-2)

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2,6-Di-tert-butylpyridine (585-48-8)

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prothionamide

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