| Weight | 540.708 g/mol |
|---|---|
| Formula | C24H36N4O6S2 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 2 |
Romidepsin (128517-07-7)
FR901228 · FR-901228 · Astella Pharma Brand of romidepsin
Score:
#371 in Microbiology
,
#1157 in Biochemistry
,
#2941 in Biology
,
#3682 in Chemistry
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- Phase I Trial of the Histone Deacetylase Inhibitor, Depsipeptide (FR901228, NSC 630176), in Patients with Refractory Neoplasms (Clinical Cancer Research, 2002)
- Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma (Journal of Clinical Oncology, 2009)
- Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report (Blood, 2001)
- FR901228, A POTENT ANTITUMOR ANTIBIOTIC, IS A NOVEL HISTONE DEACETYLASE INHIBITOR (Experimental Cell Research, 1998)
- FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY Chromobacterium violaceum No. 968 (The Journal of Antibiotics, 1994)
- Final Results From a Multicenter, International, Pivotal Study of Romidepsin in Refractory Cutaneous T-Cell Lymphoma (Journal of Clinical Oncology, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - FR901228
- FR-901228
- Astella Pharma Brand of romidepsin
- istodax
- FK228
- FR 901228
-
SMILESCC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
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- Pubchem - Romidepsin
- Wikipedia - romidepsin
Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacterium Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs.
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