| Weight | 289.762 g/mol |
|---|---|
| Formula | C16H16ClNO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
Skf-81297 (71636-61-8)
SKF 81297 · SK and F 81297 · SK and F-81297
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SMILESC1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=CC=C3
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InChIKeyGHWJEDJMOVUXEC-UHFFFAOYSA-N
- Pubchem - Skf-81297
- Wikipedia - SKF-81,297
SKF-81,297 is a synthetic drug of the benzazepine chemical class that acts as a selective dopamine D1/D5 receptor full agonist, and produces a characteristic stimulant-like pattern of anorexia, hyperactivity and self-administration in animals. This profile is shared with several related drugs such as 6-Br-APB and SKF-82,958, but not with certain other D1 full agonists such as A-77,636, reflecting functional selectivity of D1 activation. Newer findings reveal that SKF-81,297 additionally acts as a partial agonist at D1-D2 receptor heteromers.
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