| Weight | 301.515 g/mol |
|---|---|
| Formula | C18H39NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 16 |
Sphinganine (764-22-7, 3102-56-5)
dihydrosphingosine · safingol · SPC 100270
Score:
#1604 in Biochemistry
,
#3662 in Biology
,
#4596 in Chemistry
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- Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. (Journal of Biological Chemistry, 1993)
- Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. (Journal of Biological Chemistry, 1992)
- Inhibition of Phorbol Ester-dependent Differentiation of Human Promyelocytic Leukemic (HL-60) Cells by Sphinganine and Other Long-chain Bases* (Journal of Biological Chemistry, 1986)
- Alteration of Tissue and Serum Sphinganine to Sphingosine Ratio: An Early Biomarker of Exposure to Fumonisin-Containing Feeds in Pigs (Toxicology and Applied Pharmacology, 1993)
- Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. (Journal of Biological Chemistry, 2002)
- Increases in Serum Sphingosine and Sphinganine and Decreases in Complex Sphingolipids in Ponies Given Feed Containing Fumonisins, Mycotoxins Produced by Fusarium moniliforme (Journal of Nutrition, 1992)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - dihydrosphingosine
- safingol
- SPC 100270
- SPC-100270
- erythro-D-sphinganine
- saginfol
- safingol, ((R*,S*)-(+-))-isomer
- safingol hydrochloride
- safingol, (R-(R*,R*))-isomer
- 2-aminooctadecane-1,3-diol
- safingol, (S-(R*,S*))-isomer
- threo-dihydrosphingosine
-
SMILESCCCCCCCCCCCCCCCC(C(CO)N)O
-
InChIKeyOTKJDMGTUTTYMP-UHFFFAOYSA-N
- Pubchem - Sphinganine
- Wikipedia - sphinganine
Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis.
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