| Weight | 314.37 g/mol |
|---|---|
| Formula | C15H14N4O2S |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
sulfaphenazole (526-08-9)
Sulphaphenazole · Phenylsulfapyrazole · Sulfaphenylpyrazol
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- Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9 (Xenobiotica, 1995)
- SULPHAPHENAZOLE-INDUCED HYPOGLYCMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS (The Lancet, 1963)
- Interaction of Sulfaphenazole Derivatives with Human Liver Cytochromes P450 2C: Molecular Origin of the Specific Inhibitory Effects of Sulfaphenazole on CYP 2C9 and Consequences for the Substrate Binding Site Topology of CYP 2C9 (Biochemistry, 1996)
- Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers (Clinical Pharmacology & Therapeutics, 1990)
- Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid. (Archives of Biochemistry and Biophysics, 2003)
- Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine (European Journal of Clinical Pharmacology, 2001)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Sulphaphenazole
- Phenylsulfapyrazole
- Sulfaphenylpyrazol
-
SMILESC1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N
-
InChIKeyQWCJHSGMANYXCW-UHFFFAOYSA-N
- Pubchem - sulfaphenazole
- Wikipedia - sulfaphenazole
Sulfaphenazole (or sulfafenazol) is a sulfonamide antibacterial.
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Synthesis
Phenylboronic acid
+
Reactant
(N-arylation heterocycles)
Reactant
+
CID 5360334
(Chan-Lam coupling reaction)
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sulfaphenazole
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