| Weight | 253.718 g/mol |
|---|---|
| Formula | C9H8ClN5S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
tizanidine (51322-75-9)
Score:
#112 in Neurology
,
#533 in Neuroscience
,
#2439 in Biology
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- Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. (Drugs, 1997)
- Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by -adrenergic receptor antagonists (Neuropharmacology, 1991)
- Chronic Daily Headache Prophylaxis With Tizanidine: A DoubleBlind, PlaceboControlled, Multicenter Outcome Study (Headache, 2002)
- Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism. (Clinical Pharmacology & Therapeutics, 2004)
- Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study (Journal of Neurology, Neurosurgery, and Psychiatry, 2008)
- The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine. (Journal of Neurology, Neurosurgery, and Psychiatry, 1984)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl
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InChIKeyXFYDIVBRZNQMJC-UHFFFAOYSA-N
- Pubchem - tizanidine
- Wikipedia - tizanidine
Tizanidine (trade names Zanaflex (Acorda Therapeutics), Sirdalud (Novartis), Relentus (Beximco Pharma) Is a centrally acting 2 adrenergic agonist used as a muscle relaxant. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant.
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tizanidine
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