| Weight | 369.314 g/mol |
|---|---|
| Formula | C14H22Cl2N2O3S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 9 |
TLCK hydrochloride (4238-41-9, 4272-74-6)
TLCK · Tosyllysine Chloromethyl Ketone · Tosyllysyl Chloromethane
Score:
#84 in Molecular and cellular biology
,
#2390 in Biochemistry
,
#4717 in Biology
,
#5995 in Chemistry
"What do you need help with?"
LabBot
- Nonlysosomal, pre-Golgi degradation of unassembled asialoglycoprotein receptor subunits: a TLCK- and TPCK-sensitive cleavage within the ER. (Journal of Cell Biology, 1991)
- Identification of the histidine residue at the active center of trypsin labelled by TLCK. (Biochemical and Biophysical Research Communications, 1967)
- Ethanol-Induced Apoptosis in Hepatoma Cells Proceeds via Intracellular Ca2+ Elevation, Activation of TLCK-Sensitive Proteases, and Cytochrome c Release (Experimental Cell Research, 2001)
- The Serine Protease Inhibitors, Tosylphenylalanine Chloromethyl Ketone and Tosyllysine Chloromethyl Ketone, Potently Inhibit pp70s6k Activation (Journal of Biological Chemistry, 1996)
- The site of action of N-alpha-tosyl-L-lysyl-chloromethyl-ketone (TLCK) on cloned cytotoxic T lymphocytes. (Journal of Immunology, 1983)
- Serine protease inhibitors N--Tosyl-L-Lysinyl-Chloromethylketone (TLCK) and N-Tosyl-L-Phenylalaninyl-Chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases (Journal of Cellular Biochemistry, 2008)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - TLCK
- Tosyllysine Chloromethyl Ketone
- Tosyllysyl Chloromethane
- Chlorotosylamidoaminoheptanone
-
SMILESCC1=CC=C(C=C1)S(=O)(=O)NC(CCCCN)C(=O)CCl.Cl
-
InChIKeyYFCUZWYIPBUQBD-UHFFFAOYSA-N
Suppliers
Most-cited Publications
Areas of Application
Safety
Trends
Alternate Names
External Links
Synthesis
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
P-TOLUENESULFONAMIDE
+
Reactant
(Alkylation of primary amines)
Reactant
+
Dichloromethane
(Grignard carbonyl)
Similar Compounds
TLCK
(4238-41-9)
5 alternate names
3 suppliers
78521-39-8
(78521-39-8)
5 alternate names
3 suppliers
2-(Toluene-4-sulfonylamino)-succinamic acid
(62743-18-4)
5 alternate names
3 suppliers
1-tosylazetidin-3-one
(76543-27-6)
5 alternate names
3 suppliers
1-(4-Tolylsulfonyl)pyrrolidin-3-one
(73696-28-3)
5 alternate names
3 suppliers
4-amino-N-cyclohexylbenzenesulfonamide
(53668-37-4)
5 alternate names
3 suppliers
42908-33-8
(42908-33-8)
5 alternate names
3 suppliers
4-bromo-N-cyclohexylbenzenesulfonamide
(7454-76-4)
5 alternate names
3 suppliers
147636-36-0
(147636-36-0)
5 alternate names
3 suppliers
N-(3-aminopropyl)-4-methylbenzenesulfonamide
(56125-49-6)
5 alternate names
3 suppliers
1-Tosylpiperidin-4-one
(33439-27-9)
5 alternate names
3 suppliers
690646-16-3
(690646-16-3)
5 alternate names
3 suppliers
4-[(cyclopropylamino)sulfonyl]benzoic acid
(436092-71-6)
5 alternate names
3 suppliers
4-(azepan-1-ylsulfonyl)benzoic acid
(17420-68-7)
5 alternate names
3 suppliers
N-p-Tosylglycine
(1080-44-0)
5 alternate names
3 suppliers
1-[(4-methylphenyl)sulfonyl]-4-piperidinecarbohydrazide
(324531-31-9)
5 alternate names
3 suppliers
10252-83-2
(10252-83-2)
5 alternate names
3 suppliers
N-[(4-fluorophenyl)sulfonyl]-D-valine
(190275-60-6)
5 alternate names
3 suppliers
4-[(tert-butylamino)sulfonyl]benzoic acid
(99987-05-0)
5 alternate names
3 suppliers
4-[(propylamino)sulfonyl]benzoic acid
(10252-65-0)
5 alternate names
3 suppliers
159855-97-7
(159855-97-7)
5 alternate names
3 suppliers
Methyl 2-(4-methylphenylsulfonamido)acetate
(2645-02-5)
5 alternate names
3 suppliers
N-[(4-ETHYLPHENYL)SULFONYL]GLYCINE
(670255-99-9)
5 alternate names
3 suppliers
4-[(phenylsulfonyl)amino]butanoic acid
(85845-09-6)
5 alternate names
3 suppliers
4-(Pyrrolidine-1-sulfonyl)-benzoic acid
(19580-33-7)
5 alternate names
3 suppliers
7467-48-3
(7467-48-3)
5 alternate names
3 suppliers
Antidipsin
(547-35-3)
5 alternate names
3 suppliers
N-(2-chloroethyl)-4-methylbenzenesulfonamide
(6331-00-6)
5 alternate names
3 suppliers
n-tosylethylenediamine
(14316-16-6)
5 alternate names
3 suppliers
13505-32-3
(34635-34-2, 13505-32-3)
5 alternate names
3 suppliers
N,N-Diethyl-p-toluenesulfonamide
(649-15-0)
5 alternate names
3 suppliers
N-Tosylaziridine
(3634-89-7)
5 alternate names
3 suppliers
4403-78-5
(4403-78-5)
5 alternate names
3 suppliers
4-Amino-N-hexylbenzenesulfonamide
(67491-88-7)
5 alternate names
3 suppliers
AC1LF0BG
(109099-69-6)
5 alternate names
3 suppliers
122891-92-3
(122891-92-3)
5 alternate names
3 suppliers
1-(PHENYLSULFONYL)-4-PIPERIDINAMINE HYDROCHLORIDE
(1174143-24-8)
5 alternate names
3 suppliers
methyl 1-(phenylsulfonyl)-4-piperidinecarboxylate
(311794-15-7)
5 alternate names
3 suppliers
42137-88-2
(42137-88-2)
5 alternate names
3 suppliers
N-butyl-4-fluorobenzenesulfonamide
(312-67-4)
5 alternate names
3 suppliers
10252-64-9
(10252-64-9)
5 alternate names
3 suppliers
methyl 4-[(dipropylamino)sulfonyl]benzoate
(53212-75-2)
5 alternate names
3 suppliers
N,N-diallyl-4-methylbenzenesulfonamide
(50487-72-4)
5 alternate names
3 suppliers
N-tert-butylbenzenesulfonamide
(2512-24-5)
5 alternate names
3 suppliers
7311-93-5
(7311-93-5)
5 alternate names
3 suppliers
314744-43-9
(314744-43-9)
5 alternate names
3 suppliers
61714-25-8
(61714-25-8)
5 alternate names
3 suppliers
N-(2-Iodoethyl)-N,4-dimethylbenzenesulfonamide
(3409-85-6)
5 alternate names
3 suppliers
425654-95-1
(425654-95-1)
5 alternate names
3 suppliers
4-amino-N-cyclopropylbenzenesulfonamide
(177785-41-0)
5 alternate names
3 suppliers
4-amino-N-butylbenzenesulfonamide
(1829-82-9)
5 alternate names
3 suppliers
Etebenecid
(1213-06-5)
5 alternate names
3 suppliers
222409-98-5
(222409-98-5)
5 alternate names
3 suppliers
1-[(4-bromophenyl)sulfonyl]-4-piperidinecarboxylic acid
(203519-01-1)
5 alternate names
3 suppliers
4-Phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile
(24476-55-9)
5 alternate names
3 suppliers
N-[(4-fluorophenyl)sulfonyl]-beta-alanine
(208121-88-4)
5 alternate names
3 suppliers
4-methyl-N,N-di-2-propyn-1-ylbenzenesulfonamide
(18773-54-1)
5 alternate names
3 suppliers
N-[(2,4-dimethylphenyl)sulfonyl]glycine
(670255-96-6)
5 alternate names
3 suppliers
4-bromo-N-cyclopropylbenzenesulfonamide
(331950-30-2)
5 alternate names
3 suppliers
4-{[(4-methoxyphenyl)sulfonyl]amino}butanoic acid
(81242-26-4)
5 alternate names
3 suppliers
7326-79-6
(7326-79-6)
5 alternate names
3 suppliers
1984-28-7
(1984-28-7)
5 alternate names
3 suppliers
4-tosylmorpholine
(6339-26-0)
5 alternate names
3 suppliers
4-(azepan-1-ylsulfonyl)aniline
(109286-01-3)
5 alternate names
3 suppliers
1-(phenylsulfonyl)pyrrolidine
(5033-22-7)
5 alternate names
3 suppliers
1-[(4-methylphenyl)sulfonyl]piperazine
(27106-51-0)
5 alternate names
3 suppliers
36974-65-9
(36974-65-9)
5 alternate names
3 suppliers
n,n-dibutylbenzenesulfonamide
(5339-59-3)
5 alternate names
3 suppliers
3-[(isopropylamino)sulfonyl]benzoic acid
(716358-46-2)
5 alternate names
3 suppliers
56187-04-3
(56187-04-3)
5 alternate names
1 safety hazard
3 suppliers
1-[(4-tert-butylphenyl)sulfonyl]piperazine
(379244-68-5)
5 alternate names
3 suppliers
1,4-ditosylpiperazine
(17046-84-3)
5 alternate names
3 suppliers
6336-68-1
(6336-68-1)
5 alternate names
3 suppliers
4-[(4-methylpiperidin-1-yl)sulfonyl]aniline
(314285-39-7)
5 alternate names
3 suppliers
1,4,7-Tritosyl-1,4,7-triazonane
(52667-89-7)
5 alternate names
3 suppliers
1-[(4-ethylphenyl)sulfonyl]piperazine
(777879-15-9)
5 alternate names
3 suppliers
N-tert-butyl-4-fluorobenzenesulfonamide
(29083-05-4)
5 alternate names
3 suppliers
3-{4-[(methylamino)sulfonyl]phenyl}propanoic acid
(842975-38-6)
5 alternate names
3 suppliers
N-[(4-fluoro-3-methylphenyl)sulfonyl]glycine
(670260-29-4)
5 alternate names
3 suppliers
4-fluoro-N-propylbenzenesulfonamide
(433-05-6)
5 alternate names
3 suppliers
209917-48-6
(209917-48-6)
5 alternate names
3 suppliers
1-methyl-4-tosylpiperazine
(46779-48-0)
5 alternate names
3 suppliers
4-(4-tert-butylphenylsulfonyl)piperazin-2-one
(851215-92-4)
5 alternate names
3 suppliers
157187-14-9
(157187-14-9)
5 alternate names
3 suppliers
314744-44-0
(314744-44-0)
5 alternate names
3 suppliers
834-66-2
(834-66-2)
5 alternate names
3 suppliers
4-amino-N-propylbenzenesulfonamide
(58687-83-5)
5 alternate names
3 suppliers
4-(pyrrolidin-1-ylsulfonyl)aniline
(88327-91-7)
5 alternate names
3 suppliers
93281-65-3
(93281-65-3)
5 alternate names
3 suppliers
AC1LHH2S
(109069-00-3)
5 alternate names
3 suppliers
20491-97-8
(20491-97-8)
5 alternate names
3 suppliers
2-(4-tosylpiperazin-1-yl)ethanol
(16017-64-4)
5 alternate names
3 suppliers
4-amino-N-isopropylbenzenesulfonamide
(53668-35-2)
5 alternate names
3 suppliers
N-Methyl-p-toluenesulfonamide
(640-61-9)
5 alternate names
3 suppliers
1-[(3,4-dimethylphenyl)sulfonyl]piperazine
(524711-31-7)
5 alternate names
3 suppliers
61714-27-0
(61714-27-0)
5 alternate names
3 suppliers
332400-85-8
(332400-85-8)
5 alternate names
3 suppliers
TLCK hydrochloride
CAS Directory
