| Weight | 424.552 g/mol |
|---|---|
| Formula | C26H28N6 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 4 |
| Rotatable Bonds | 11 |
TPEN (16858-02-9)
Score:
#24 in Inorganic chemistry
,
#2348 in Biochemistry
,
#4658 in Biology
,
#5912 in Chemistry
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- Isoquinoline-based TQEN family as TPEN-derived fluorescent zinc sensors. (Inorganic Chemistry, 2008)
- Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells (Investigative Ophthalmology & Visual Science, 2001)
- TPEN, a Zn2+/Fe2+ chelator with low affinity for Ca2+, inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro (Cell Calcium, 1998)
- Solvent extraction separation of Cd(II) and Zn(II) with the organophosphorus extractant D2EHPA and the aqueous nitrogen-donor ligand TPEN (Hydrometallurgy, 2003)
- Protection by the heavy metal chelator N,N,N,N-tetrakis (2-Pyridylmethyl)ethylenediamine (TPEN) against the lethal action of botulinum neurotoxin A and B (Toxicon, 1997)
- Prevention of zinc neurotoxicity in vivo by N,N,N',N'-tetrakis (2-pyridylmethyl) ethylene-diamine (TPEN). (Neuroreport, 1996)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
-
InChIKeyCVRXLMUYFMERMJ-UHFFFAOYSA-N
- Pubchem - TPEN
- Wikipedia - N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
TPEN (N,N,N,N-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine) is an intracellular membrane-permeable ion chelator for zinc. Chelators can be used in chelation therapy to remove toxic metals in the body. TPEN is a chelator that has a high affinity for zinc.
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Synthesis
Pyridin-2-ylmethylboronic acid
+
1,2-Ethanediamine, N,N,N'-tris(2-pyridinylmethyl)-
(Chan-Lam coupling reaction)
Similar Compounds
1-(pyridin-2-ylmethyl)piperazine
(55579-01-6)
1 alternate name
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ZX-CM014386
(1609404-09-2)
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N-(2-pyridinylmethyl)ethanamine
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58669-30-0
(58669-30-0)
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N-methyl-N-(2-pyridinylmethyl)glycine dihydrochloride hydrate
(1315173-05-7)
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N-(2-pyridinylmethyl)-2-propen-1-amine
(62402-16-8)
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1539-42-0
(1539-42-0)
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bis(pyridin-2-ylmethyl)amine
(1539-42-0)
1 alternate name
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N-(2-pyridinylmethyl)-1-propanamine
(51639-59-9)
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1-(pyridin-2-ylmethyl)piperidin-4-amine
(160357-91-5)
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6636-71-1
(6636-71-1)
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1-[(3-methylpyridin-2-yl)methyl]piperazine
(524673-92-5)
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1-Pyridin-2-ylmethylpiperidin-4-one
(41661-56-7)
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N-(2-pyridinylmethyl)-1-butanamine
(58061-48-6)
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Cyclopropyl-pyridin-2-ylmethyl-amine
(626210-44-4)
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Ambcb9037788
(1049713-04-3)
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DMAP amine
(21035-59-6)
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6971-57-9
(6971-57-9)
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Ambcb9040273
(1049713-06-5)
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(2-phenylethyl)(pyridin-2-ylmethyl)amine
(418776-49-5)
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2-bromo-N-(2-pyridinylmethyl)acetamide hydrochloride
(1638221-28-9)
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N-benzyl-1-(6-methyl-2-pyridinyl)methanamine hydrochloride
(1185293-34-8)
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N-benzyl-1-(6-methylpyridin-2-yl)methanamine
(101938-10-7)
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N-[(3-methylpyridin-2-yl)methyl]propan-2-amine
(915923-23-8)
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2168-13-0
(2168-13-0)
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N,N-dimethyl-1-(1H-pyrrol-2-yl)methanamine
(14745-84-7)
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Ambcb4004617
(1184987-92-5)
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3 suppliers
ZX-CM015826
(1609408-97-0)
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N~1~,N~1~-dimethyl-1-pyridin-2-ylethane-1,2-diamine
(933756-92-4)
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3 suppliers
1-(4,6-dimethylpyridin-2-yl)-N-methylmethanamine
(1083368-48-2)
1 alternate name
3 suppliers
AC1LGJLR
(202199-02-8)
1 alternate name
3 suppliers
1-(1H-pyrrol-2-ylcarbonyl)piperazine hydrochloride
(1269228-76-3)
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3 suppliers
(5R)-5-{[(2-pyridinylmethyl)amino]methyl}-2-pyrrolidinone dihydrochloride
(1982987-83-6)
1 alternate name
3 suppliers
N-methyl-N-(2-pyridinylmethyl)guanidine sulfate
(1609396-36-2)
1 alternate name
3 suppliers
2-Picolylamine
(3731-51-9)
1 alternate name
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1-Picolinoylpiperidin-4-one
(948853-54-1)
1 alternate name
3 suppliers
ZX-CM017701
(1050213-87-0)
1 alternate name
3 suppliers
247571-56-8
(247571-56-8)
1 alternate name
3 suppliers
[(4-methoxy-2-pyridinyl)methyl]methylamine dihydrochloride
(1559059-77-6)
1 alternate name
3 suppliers
1-(4-methoxypyridin-2-yl)-N-methylmethanamine
(936940-51-1)
1 alternate name
3 suppliers
(6-methylpyridin-2-yl)methanamine
(6627-60-7)
1 alternate name
3 suppliers
4-{[(2-PYRIDINYLMETHYL)AMINO]METHYL}BENZOIC ACID HYDROCHLORIDE
(1052516-42-3)
1 alternate name
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(2-morpholin-4-yl-2-pyridin-2-ylethyl)amine
(933735-22-9)
1 alternate name
3 suppliers
(4-methoxybenzyl)(pyridin-2-ylmethyl)amine
(121020-62-0)
1 alternate name
3 suppliers
6-Benzyl-6,7-dihydro-5H-pyrrolo[3,4-B]pyridine
(109966-30-5)
1 alternate name
3 suppliers
1-(5-ethylpyridin-2-yl)-N-methylmethanamine
(114366-10-8)
1 alternate name
3 suppliers
N-methyl-1-(3-methylpyridin-2-yl)methanamine
(880361-72-8)
1 alternate name
3 suppliers
n-benzyl-1-(3-methyl-2-pyridinyl)methanamine dihydrochloride
(1269198-98-2)
1 alternate name
3 suppliers
N-(pyridin-2-ylmethyl)piperidine-4-carboxamide
(884497-59-0)
1 alternate name
3 suppliers
(2-furylmethyl)(2-pyridinylmethyl)amine oxalate
(1158770-65-0)
1 alternate name
3 suppliers
N-methyl-1-quinolin-2-ylmethanamine
(136727-11-2)
1 alternate name
3 suppliers
1-(2-pyridinylcarbonyl)-4-piperidinecarboxylic acid
(67691-62-7)
1 alternate name
3 suppliers
6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
(147739-88-6)
1 alternate name
3 suppliers
(5-Methylpyridin-2-yl)methanamine dihydrochloride
(357287-98-0)
1 alternate name
3 suppliers
[(3-methyl-2-thienyl)methyl](2-pyridinylmethyl)amine hydrochloride
(1050214-47-5)
1 alternate name
3 suppliers
(4-methylpyridin-2-yl)methanamine
(129768-95-2)
1 alternate name
3 suppliers
(4-Methylpyridin-2-yl)methanamine dihydrochloride
(357287-88-8)
1 alternate name
3 suppliers
N-methyl-1-pyridin-2-ylpropan-1-amine
(959238-83-6)
1 alternate name
3 suppliers
2-Pyrrolidin-2-ylpyridine
(77790-61-5)
1 alternate name
3 suppliers
2-(pyrrolidin-2-yl)pyridine dihydrochloride
(1228879-12-6)
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3 suppliers
N-benzylpyridine-2-carboxamide
(18904-38-6)
1 alternate name
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(4-Methoxypyridin-2-yl)methanamine
(194658-14-5)
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2-(3,4-dimethoxyphenyl)-N-(pyridin-2-ylmethyl)ethanamine
(99615-36-8)
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2-(Piperidin-2-yl)pyridine dihydrochloride
(143924-44-1)
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2-(piperidin-2-yl)pyridine
(15578-73-1)
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(R)-1-(Pyridin-2-yl)ethanamine
(42088-91-5)
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2-(AZIDOMETHYL)PYRIDINE
(609770-35-6)
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(1,3-benzodioxol-5-ylmethyl)(2-pyridinylmethyl)amine dihydrobromide
(1609406-32-7)
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(1,3-benzodioxol-5-ylmethyl)(pyridin-2-ylmethyl)amine
(626210-49-9)
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pyridine-2-carbothioamide
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1-(6-methyl-2-pyridinyl)ethanamine
(58088-67-8)
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1-[(1-methyl-1H-pyrrol-2-yl)methyl]-4-piperidinecarboxylic acid hydrate
(1269039-36-2)
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1-[(1-methyl-1H-pyrrol-2-yl)methyl]-4-piperidinecarboxylic acid
(1177281-06-9)
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6-chloro-N,N-dimethylpyridine-2-carboxamide
(845306-05-0)
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5-oxo-1-(pyridin-2-ylmethyl)pyrrolidine-3-carboxylic acid
(845546-25-0)
1 alternate name
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Picolinamide
(1452-77-3)
1 alternate name
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isoquinolin-1-ylmethanamine
(40615-08-5)
1 alternate name
3 suppliers
(2-methoxy-1-pyridin-2-ylethyl)methylamine
(959238-90-5)
1 alternate name
3 suppliers
quinolin-2-ylmethanamine dihydrochloride
(18004-62-1)
1 alternate name
3 suppliers
2-amino-N-(2-pyridinylmethyl)benzamide
(57786-49-9)
1 alternate name
3 suppliers
1-(pyridin-3-ylmethyl)piperazine
(39244-80-9)
1 alternate name
3 suppliers
[1-(2-pyridinyl)propyl]amine dihydrochloride
(1228880-20-3)
1 alternate name
3 suppliers
1-(2-Pyridyl)-1-propylamine
(100155-73-5)
1 alternate name
3 suppliers
[(3-chloro-2-pyridinyl)methyl]amine dihydrochloride
(342816-31-3)
1 alternate name
3 suppliers
1-(pyridin-4-ylmethyl)piperazine
(62089-74-1)
1 alternate name
3 suppliers
147732-31-8
(147732-31-8)
1 alternate name
3 suppliers
1-(6-Methylpyridin-2-yl)propan-1-amine
(1185320-33-5)
1 alternate name
3 suppliers
1-(PYRIDIN-3-YLMETHYL)-1,4-DIAZEPANE
(874814-64-9)
1 alternate name
3 suppliers
1-(5-methyl-2-pyridinyl)ethanamine
(885277-04-3)
1 alternate name
3 suppliers
1-[(4-bromo-1H-pyrrol-2-yl)carbonyl]piperidine
(900019-45-6)
1 alternate name
3 suppliers
4-Chloro-N-methylpicolinamide
(220000-87-3)
1 alternate name
3 suppliers
Phenyl-pyridin-2-ylmethyl-amine
(4329-81-1)
1 alternate name
3 suppliers
[1-(4-methyl-2-pyridinyl)ethyl]amine dihydrochloride
(1187932-01-9)
1 alternate name
3 suppliers
1-(4-methyl-2-pyridinyl)ethanamine
(58088-63-4)
1 alternate name
3 suppliers
potassium 4-morpholinyl(2-pyridinyl)acetate
(1246553-34-3)
1 alternate name
3 suppliers
[cyclopropyl(2-pyridinyl)methyl]methylamine dihydrochloride
(1269044-11-2)
1 alternate name
3 suppliers
6-chloro-N-methyl-2-pyridinecarboxamide
(845306-04-9)
1 alternate name
3 suppliers
1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine hydrochloride
(1609400-14-7)
1 alternate name
3 suppliers
1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
(71257-38-0)
1 alternate name
3 suppliers
TPEN
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