| Weight | 284.359 g/mol |
|---|---|
| Formula | C17H20N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
tropisetron (89565-68-4)
Score:
#871 in Neuroscience
,
#3823 in Biology
,
#4815 in Chemistry
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- Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo (Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 1996)
- The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective 7 nicotinic receptor partial agonist (Bioorganic & Medicinal Chemistry Letters, 2001)
- Tropisetron improves deficits in auditory P50 suppression in schizophrenia (Schizophrenia Research, 2005)
- Efficacy and tolerability of tropisetron in primary fibromyalgia - a highly selective and competitive 5-HT3 receptor antagonist (Scandinavian Journal of Rheumatology, 2000)
- Tropisetron: An update of its use in the prevention of chemotherapy-induced nausea and vomiting (Drugs, 2000)
- The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. (Drug Metabolism and Disposition, 1994)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
-
InChIKeyZNRGQMMCGHDTEI-UHFFFAOYSA-N
- Pubchem - tropisetron
- Wikipedia - Tropisetron
Tropisetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. The drug is available in a 5mg oral preparation or in 2mg intravenous form. It is marketed by Novartis in Europe, Australia, New Zealand, Japan, South Korea and the Philippines as Navoban, but is not available in the U.S.
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Synthesis
Indole-3-carboxylic acid
+
3-Chloro-8-methyl-8-azabicyclo[3.2.1]octane
(Ester from carboxilic acid(SN2))
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