| Weight | 176.219 g/mol |
|---|---|
| Formula | C10H12N2O |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
1,2,3,4-tetrahydroisoquinoline-3-carboxamide (112794-29-3)
112794-29-3 · 1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
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- Sigma-Aldrich - Search for 1,2,3,4-tetrahydroisoquinoline-3-carboxamide
- Fisher Scientific - Search for 1,2,3,4-tetrahydroisoquinoline-3-carboxamide
- TCI - Search for 1,2,3,4-tetrahydroisoquinoline-3-carboxamide
- Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid Receptor Antagonist (Journal of Medicinal Chemistry, 2003)
- Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3, 4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats (Psychopharmacology, 2010)
- Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). (Journal of Medicinal Chemistry, 2008)
- Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and In Vitro and In Vivo Opioid Receptor Antagonist Activity (Journal of Medicinal Chemistry, 2010)
- Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) (Journal of Medicinal Chemistry, 2009)
- Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile. (Journal of Medicinal Chemistry, 2014)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 112794-29-3
- 1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
-
SMILESC1C(NCC2=CC=CC=C21)C(=O)N
-
InChIKeyJFMNKDRNEZZRBW-UHFFFAOYSA-N
Suppliers
Most-cited Publications
Safety
Alternate Names
Estimated Properties
| Boiling Point | 294.77 C | EPA T.E.S.T. |
|---|---|---|
| Boiling Point | 366.11 C | EPI Suite |
| Density | 1.13 g/cm3 | EPA T.E.S.T. |
| Flash Point | 174.9 C | EPA T.E.S.T. |
| Melting Point | 144.65 C | EPI Suite |
| Water Solubility | 2906.48 mg/L | EPA T.E.S.T. |
| Water Solubility | 550060 mg/L | EPI Suite |
External Links
Synthesis
2-Methylbenzylamine
+
Reactant
(Alkylation of primary amines)
Similar Compounds
[(2-methyl-1,2,3,4-tetrahydro-3-isoquinolinyl)methyl]amine dihydrochloride
(54329-62-3)
3 alternate names
3 suppliers
41994-51-8
(35186-99-3, 41994-51-8)
3 alternate names
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N-methyl-1-(2-methyl-1,2,3,4-tetrahydro-3-isoquinolinyl)methanamine dihydrochloride
(1609396-53-3)
3 alternate names
3 suppliers
2-methyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
(20335-68-6)
3 alternate names
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2-formyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(61047-23-2)
3 alternate names
3 suppliers
ethyl 1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride
(57980-74-2)
3 alternate names
3 suppliers
2-ethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
(1101199-16-9)
3 alternate names
3 suppliers
AK306774
(1609400-78-3)
3 alternate names
3 suppliers
1-OXO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
(63586-82-3)
3 alternate names
3 suppliers
1,2,3,4-Tetrahydroisoquinoline
(91-21-4, 14099-81-1)
3 alternate names
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2-(3,4-dihydroisoquinolin-2(1H)-yl)ethanamine
(53356-51-7)
3 alternate names
3 suppliers
[2-(3,4-dihydro-2(1H)-isoquinolinyl)ethyl]amine dihydrochloride
(300578-48-7)
3 alternate names
3 suppliers
1-(3,4-Dihydroisoquinolin-2(1H)-yl)propan-2-amine
(54151-52-9)
3 alternate names
3 suppliers
1,4-Dihydro-3(2H)-isoquinolinone
(24331-94-0)
3 alternate names
3 suppliers
2-(3,4-dihydro-2(1H)-isoquinolinyl)propanoic acid hydrochloride hydrate
(938350-35-7)
3 alternate names
3 suppliers
3,4-dihydro-2(1H)-isoquinolinylacetic acid hydrochloride
(200064-94-4)
3 alternate names
3 suppliers
(3,4-Dihydro-1H-isoquinolin-2-yl)-acetic acid
(731810-79-0)
3 alternate names
3 suppliers
AC1LUGHA
(105400-81-5)
3 alternate names
3 suppliers
1-Methyl-1,2,3,4-tetrahydroisoquinoline
(4965-09-7)
3 alternate names
3 suppliers
3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-1-ol
(86368-07-2)
3 alternate names
3 suppliers
1,2,3,4-tetrahydroisoquinolin-6-ol
(14446-24-3)
3 alternate names
3 suppliers
Norbenzphetamine
(1085-42-3, 57378-23-1)
3 alternate names
3 suppliers
1,2,3,4-tetrahydroisoquinolin-7-ol Hydrochloride
(66393-01-9)
3 alternate names
3 suppliers
1,2,3,4-tetrahydroisoquinolin-7-ol
(30798-64-2)
3 alternate names
3 suppliers
2-(3-chloropropanoyl)-1,2,3,4-tetrahydroisoquinoline
(10579-67-6)
3 alternate names
3 suppliers
2-(3,4-Dihydroisoquinolin-2(1H)-yl)ethanol
(88014-15-7)
3 alternate names
3 suppliers
6-(methylthio)-1,2,3,4-tetrahydroisoquinoline hydrochloride
(90265-88-6)
3 alternate names
3 suppliers
2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
(14097-39-3)
3 alternate names
3 suppliers
115962-35-1
(115962-35-1)
3 alternate names
3 suppliers
2-(piperidin-4-yl)-1,2,3,4-tetrahydroisoquinoline
(200413-62-3)
3 alternate names
3 suppliers
2-(4-piperidinyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride
(871113-10-9)
3 alternate names
3 suppliers
3,4-dihydro-1(2H)-isoquinolinone
(1196-38-9)
3 alternate names
3 suppliers
40073-45-8
(40073-45-8)
3 alternate names
3 suppliers
1',3'-dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione
(27473-61-6)
3 alternate names
3 suppliers
(3S)-3-benzyl-2-piperazinone hydrochloride
(1212300-41-8)
3 alternate names
3 suppliers
7-bromo-1,2,3,4-tetrahydroisoquinoline
(17680-55-6)
3 alternate names
3 suppliers
5-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
(799274-05-8)
3 alternate names
3 suppliers
3,4-dihydro-2(1H)-isoquinolinyl(oxo)acetic acid
(603097-44-5)
3 alternate names
3 suppliers
3,4-dihydroisoquinoline-2(1H)-carbothioamide
(31964-52-0)
3 alternate names
3 suppliers
6-Methoxy-1,2,3,4-tetrahydroisoquinoline
(42923-77-3)
3 alternate names
3 suppliers
NSC174635
(59433-90-8)
3 alternate names
3 suppliers
7-methoxy-1,2,3,4-tetrahydroisoquinoline
(43207-78-9)
3 alternate names
3 suppliers
1,2,3,4-tetrahydro-4-isoquinolinol hydrochloride
(13691-36-6)
3 alternate names
3 suppliers
1,2,3,4-tetrahydro-4-isoquinolinol
(51641-23-7)
3 alternate names
3 suppliers
4-(3,4-dihydro-2(1H)-isoquinolinylmethyl)benzoic acid
(333357-96-3)
3 alternate names
3 suppliers
Isoquinoline-1,3(2H,4H)-dione
(4456-77-3)
3 alternate names
3 suppliers
Clobenzorex hydrochloride
(1048649-80-4, 5843-53-8)
3 alternate names
3 suppliers
7-Methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
(1011-43-4)
3 alternate names
3 suppliers
N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)alanine
(537049-19-7)
3 alternate names
3 suppliers
N~1~,N~1~-dimethyl-1-(2-methylphenyl)-1,2-ethanediamine
(928000-19-5)
3 alternate names
3 suppliers
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
(1745-07-9)
3 alternate names
3 suppliers
43229-65-8
(43229-65-8, 245759-64-2)
3 alternate names
3 suppliers
1-Phenyl-1,2,3,4-tetrahydroisoquinoline
(22990-19-8)
3 alternate names
3 suppliers
30189-48-1
(30189-48-1)
3 alternate names
3 suppliers
7-amino-3,4-dihydro-1(2H)-isoquinolinone
(66491-03-0)
3 alternate names
3 suppliers
2-Methylisoquinoline-1,3(2H,4H)-dione
(4494-53-5)
3 alternate names
3 suppliers
N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
(64037-95-2, 10409-15-1)
3 alternate names
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1,2,3,4-tetrahydronaphthalen-2-amine
(2954-50-9)
3 alternate names
3 suppliers
2954-50-9
(2954-50-9)
3 alternate names
3 suppliers
1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride
(1743-01-7)
3 alternate names
3 suppliers
6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone
(21763-07-5)
3 alternate names
3 suppliers
2-(2-methylphenyl)-2-(4-methylpiperidin-1-yl)ethanamine
(915922-08-6)
3 alternate names
3 suppliers
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
(5784-74-7)
3 alternate names
3 suppliers
883-87-4
(883-87-4)
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3 suppliers
1-Aminoindan
(61949-83-5, 34698-41-4)
3 alternate names
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4-phenylazetidin-2-one
(5661-55-2)
3 alternate names
3 suppliers
(pyridin-4-ylmethyl)1,2,3,4-tetrahydronaphthalen-1-ylamine
(884497-50-1)
3 alternate names
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N-(4-pyridinylmethyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrobromide
(1208869-71-9)
3 alternate names
3 suppliers
N-methyl-2-indanamine hydrochloride
(10408-85-2)
3 alternate names
3 suppliers
3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride
(195987-27-0)
3 alternate names
3 suppliers
27473-62-7
(27473-62-7)
3 alternate names
3 suppliers
Phe-phe-ome
(13082-29-6)
3 alternate names
3 suppliers
1-(1,2,3,4-tetrahydronaphthalen-2-yl)piperazine
(1900-04-5)
3 alternate names
3 suppliers
ZX-CM015644
(1609403-86-2)
3 alternate names
3 suppliers
134924-71-3
(60743-58-0, 134924-68-8, 134924-71-3)
3 alternate names
3 suppliers
2,6-Dimethyl-L-tyrosine
(123715-02-6)
3 alternate names
3 suppliers
N-Acetyl-DL-phenylalanine
(2901-75-9)
3 alternate names
3 suppliers
2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinesulfonyl chloride
(74291-57-9)
3 alternate names
3 suppliers
ZX-CM015649
(1609406-94-1)
3 alternate names
3 suppliers
1,2,3,4-Tetrahydro-1-naphthylamine
(2217-40-5)
3 alternate names
3 suppliers
AC1LFB64
(356092-08-5)
3 alternate names
3 suppliers
ZX-CM015784
(1609399-86-1)
3 alternate names
3 suppliers
3-amino-3-(2,4-dimethylphenyl)propanoic acid
(117391-54-5)
3 alternate names
3 suppliers
N-(2-methylbenzyl)-2-propanamine hydrochloride
(1158564-36-3)
3 alternate names
3 suppliers
14498-33-0
(14498-33-0)
3 alternate names
3 suppliers
Calycotomine
(4356-47-2)
3 alternate names
3 suppliers
1-(o-Tolyl)cyclopropanamine hydrochloride
(1134701-31-7)
3 alternate names
3 suppliers
N-propyl-2-indanamine hydrochloride
(74220-93-2)
3 alternate names
3 suppliers
AC1LGBVB
(355381-61-2)
3 alternate names
3 suppliers
AC1LICZZ
(1022918-77-9)
3 alternate names
3 suppliers
1,3-dihydro-2H-isoindol-2-ylacetic acid hydrochloride
(1215322-31-8)
3 alternate names
3 suppliers
1-(2-METHYLBENZYL)CYCLOPROPANAMINE HYDROCHLORIDE
(29812-96-2)
3 alternate names
3 suppliers
1-(2,4-DIMETHYLPHENYL)PROPAN-1-AMINE HYDROCHLORIDE
(856563-03-6, 1268982-48-4, 1032114-81-0)
3 alternate names
3 suppliers
1-(2,4-dimethylphenyl)propan-1-amine
(886496-82-8)
3 alternate names
3 suppliers
N-(2-METHYLBENZYL)-2-BUTANAMINE HYDROCHLORIDE
(1049750-39-1)
3 alternate names
3 suppliers
PYRIDIN-3-YLMETHYL-(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMINE HYDROBROMIDE
(1052526-84-7)
3 alternate names
3 suppliers
2-hydroxyisoquinoline-1,3(2H,4H)-dione
(6890-08-0)
3 alternate names
3 suppliers
1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CAS Directory
