| Weight | 148.114 g/mol |
|---|---|
| Formula | C5H8O5 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 4 |
2-hydroxyglutaric acid (2889-31-8)
alpha-hydroxyglutarate · D-2-hydroxyglutarate · 2-hydroxyglutarate
Score:
#833 in Neuroscience
,
#1601 in Biochemistry
,
#3659 in Biology
,
#4590 in Chemistry
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- D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function (Genes & Development, 2012)
- Mutations in the D-2-Hydroxyglutarate Dehydrogenase Gene Cause D-2-Hydroxyglutaric Aciduria (American Journal of Human Genetics, 2005)
- Stable-isotope dilution analysis of D- and L-2-hydroxyglutaric acid: application to the detection and prenatal diagnosis of D- and L-2-hydroxyglutaric acidemias. (Pediatric Research, 1993)
- D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. (European Journal of Neuroscience, 2003)
- Measurement of Urinary d- and l-2-Hydroxyglutarate Enantiomers by Stable-Isotope-Dilution Liquid ChromatographyTandem Mass Spectrometry after Derivatization with Diacetyl-l-Tartaric Anhydride (Clinical Chemistry, 2004)
- Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro (Biochimica et Biophysica Acta, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - alpha-hydroxyglutarate
- D-2-hydroxyglutarate
- 2-hydroxyglutarate
- alpha-hydroxyglutarate, (D)-isomer
- alpha-hydroxyglutarate, disodium salt
- alpha-hydroxyglutarate, (DL)-isomer
- alpha-hydroxyglutarate, (L)-isomer
-
SMILESC(CC(=O)O)C(C(=O)O)O
-
InChIKeyHWXBTNAVRSUOJR-UHFFFAOYSA-N
- Pubchem - 2-hydroxyglutaric acid
- Wikipedia - 2-hydroxyglutaric acid
-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid form of glutaric acid.
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Synthesis
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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