| Weight | 109.132 g/mol |
|---|---|
| Formula | C5H7N3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
3,4-DIAMINOPYRIDINE (54-96-6)
amifampridine · Firdapse · amifampridine phosphate
Score:
#196 in Neurology
,
#870 in Neuroscience
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#3811 in Biology
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#4797 in Chemistry
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- 3,4-Diaminopyridine in the Treatment of LambertEaton Myasthenic Syndrome (The New England Journal of Medicine, 1989)
- Treatment of downbeat nystagmus with 3,4-diaminopyridine: A placebo-controlled study (Neurology, 2003)
- Potency of 3,4-Diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH changes (European Journal of Pharmacology, 1980)
- 3,4-diaminopyridine. A potent new potassium channel blocker. (Biophysical Journal, 1978)
- A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome (Neurology, 2000)
- Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake. (Journal of Biological Chemistry, 1983)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - amifampridine
- Firdapse
- amifampridine phosphate
-
SMILESC1=CN=CC(=C1N)N
-
InChIKeyOYTKINVCDFNREN-UHFFFAOYSA-N
- Pubchem - 3,4-DIAMINOPYRIDINE
- Wikipedia - amifampridine
Amifampridine (pyridine-3,4-diamine, 3,4-diaminopyridine, 3,4-DAP) is used as a drug, predominantly in the treatment of a number of rare muscle diseases. The free base form of the drug has been used to treat congenital myasthenic syndromes and LambertEaton myasthenic syndrome (LEMS) through compassionate use programs since the 1990s and was recommended as a first line treatment for LEMS in 2006, using ad hoc forms of the drug, since there was no marketed form. Around 2000 doctors at Assistance Publique Hpitaux de Paris created a phosphate salt form, which was developed through a series of companies ending with BioMarin Pharmaceutical which obtained European approval in 2009 under the trade name Firdapse, and which licensed the US rights to Catalyst Pharmaceuticals in 2012.
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Similar Compounds
N4-methylpyridine-3,4-diamine
(1839-17-4)
4 alternate names
3 suppliers
3-AMINOPYRIDINE
(462-08-8)
4 alternate names
3 suppliers
pyridine-3,5-diamine
(4318-78-9)
4 alternate names
3 suppliers
5-bromopyridine-3,4-diamine
(4635-08-9)
4 alternate names
3 suppliers
3-Hydrazinylpyridine dihydrochloride
(364727-74-2)
4 alternate names
3 suppliers
N-methylpyridin-3-amine
(18364-47-1)
4 alternate names
3 suppliers
4-aminopyridine
(504-24-5)
4 alternate names
3 safety hazards
3 suppliers
3-Amino-4-nitropyridine
(13505-02-7)
4 alternate names
3 suppliers
2-chloropyridine-3,4-diamine
(39217-08-8)
4 alternate names
3 suppliers
2,3-Diaminopyridine
(452-58-4)
4 alternate names
3 suppliers
3-Amino-4-methylpyridine
(3430-27-1)
4 alternate names
3 suppliers
3-Amino-4-iodopyridine
(105752-11-2)
4 alternate names
3 suppliers
2,5-DIAMINOPYRIDINE
(4318-76-7)
4 alternate names
3 suppliers
2,5-Diaminopyridine dihydrochloride
(26878-35-3)
4 alternate names
3 suppliers
5-Amino-2-methylpyridine
(3430-14-6)
4 alternate names
3 suppliers
3-Amino-4-chloropyridine
(20511-15-3)
4 alternate names
3 suppliers
3-Amino-5-bromopyridine
(13535-01-8)
4 alternate names
3 suppliers
3-Amino-6-bromopyridine
(13534-97-9)
4 alternate names
3 suppliers
N,N-dimethylpyridin-3-amine
(18437-57-5)
4 alternate names
3 suppliers
4-Hydrazinopyridine
(27256-91-3)
4 alternate names
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4-hydrazinylpyridine hydrochloride
(20815-52-5)
4 alternate names
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4-Amino-3-nitropyridine
(1681-37-4)
4 alternate names
3 suppliers
N-methylpyridin-4-amine
(1121-58-0)
4 alternate names
3 suppliers
3-Amino-5-chloropyridine
(22353-34-0)
4 alternate names
3 suppliers
5-Amino-2-fluoropyridine
(1827-27-6)
4 alternate names
3 suppliers
5-AMINO-2-HYDROXYPYRIDINE
(33630-94-3)
4 alternate names
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3-Amino-2-bromopyridine
(39856-58-1)
4 alternate names
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5-Amino-2-iodopyridine
(29958-12-1)
4 alternate names
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3-Amino-2-picoline
(3430-10-2)
4 alternate names
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N-pyridin-3-ylethane-1,2-diamine
(62491-92-3)
4 alternate names
3 suppliers
5-Amino-2-chloropyridine
(5350-93-6)
4 alternate names
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2-Chloro-N4-methylpyridine-3,4-diamine
(50432-67-2)
4 alternate names
3 suppliers
3-Amino-2-hydroxypyridine
(33630-99-8)
4 alternate names
3 suppliers
N-pyridin-3-ylpropane-1,3-diamine
(938459-11-1)
4 alternate names
3 suppliers
3-Amino-2-chloropyridine
(6298-19-7)
4 alternate names
3 suppliers
4-Dimethylaminopyridine
(1122-58-3)
4 alternate names
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4-(4-methylpiperazin-1-yl)pyridin-3-amine
(14549-59-8)
4 alternate names
3 suppliers
pyridine-2,4-diamine
(461-88-1)
4 alternate names
3 suppliers
N2-Methylpyridine-2,3-diamine
(5028-20-6)
4 alternate names
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2,6-dibromopyridin-3-amine
(39856-57-0)
4 alternate names
3 suppliers
4-Aminoisoquinoline
(23687-25-4)
4 alternate names
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3-Amino-2,6-dimethylpyridine
(3430-33-9)
4 alternate names
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30162-37-9
(30162-37-9)
4 alternate names
3 suppliers
4-Amino-3,5-dinitropyridine
(31793-29-0)
4 alternate names
3 suppliers
3-Methylpyridin-4-amine
(1990-90-5)
4 alternate names
3 suppliers
n-methyl-3-nitropyridin-4-amine
(1633-41-6)
4 alternate names
3 suppliers
N-Phenylpyridin-4-amine
(22961-45-1)
4 alternate names
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N2-Methylpyridine-2,5-diamine
(28020-36-2)
4 alternate names
3 suppliers
3-AMINOQUINOLINE
(580-17-6)
4 alternate names
3 suppliers
4-Amino-2-bromopyridine
(7598-35-8)
4 alternate names
3 suppliers
1,5-Naphthyridin-3-amine
(14756-77-5)
4 alternate names
3 suppliers
4-methylpyridine-2,3-diamine
(53929-59-2)
4 alternate names
3 suppliers
3-Acetamidopyridine
(5867-45-8)
4 alternate names
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2-(methylthio)pyridin-3-amine hydrochloride
(1353976-60-9)
4 alternate names
3 suppliers
5-Amino-2-methoxypyridine
(6628-77-9)
4 alternate names
3 suppliers
2,3-Diamino-5-bromopyridine
(38875-53-5)
4 alternate names
3 suppliers
4-AMINO-3-BROMOPYRIDINE
(13534-98-0)
4 alternate names
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3-Amino-2,6-dichloropyridine
(62476-56-6)
4 alternate names
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2,6-Diamino-3-nitrosopyridine
(89323-10-4)
4 alternate names
3 suppliers
5-chloropyridine-2,3-diamine
(25710-20-7)
4 alternate names
3 suppliers
4,6-dibromopyridin-3-amine
(50786-37-3)
4 alternate names
3 suppliers
Phenazine-2,3-diamine
(655-86-7)
4 alternate names
3 suppliers
4-Nitropyridine
(1122-61-8)
4 alternate names
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N~2~,N~2~-dimethylpyridine-2,3-diamine dihydrochloride
(1177350-84-3)
4 alternate names
3 suppliers
N5,N5-Dimethylpyridine-2,5-diamine
(39856-52-5)
4 alternate names
3 suppliers
4-Amino-3-chloropyridine
(19798-77-7)
4 alternate names
3 suppliers
N2,N2-Dimethylpyridine-2,5-diamine dihydrochloride
(26878-31-9)
4 alternate names
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N2,N2-Dimethylpyridine-2,5-diamine
(4928-43-2)
4 alternate names
3 suppliers
42242-11-5
(42242-11-5)
4 alternate names
3 suppliers
4-ethoxypyridin-3-amine
(1633-43-8)
4 alternate names
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4-amino-3,5-dibromopyridine
(84539-34-4)
4 alternate names
3 suppliers
34955-25-4
(34955-25-4)
4 alternate names
3 suppliers
4-Amino-2-chloropyridine
(14432-12-3)
4 alternate names
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2,6-Dimethylpyridin-4-amine
(3512-80-9)
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8-AMINOQUINOLINE
(578-66-5)
4 alternate names
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4-Amino-3-iodopyridine
(88511-27-7)
4 alternate names
3 suppliers
4-Hydrazino-3-methylpyridine hydrochloride
(1195782-30-9)
4 alternate names
3 suppliers
1005-31-8
(1005-31-8)
4 alternate names
3 suppliers
4-Amino-2,6-dichloropyridine
(2587-02-2)
4 alternate names
3 suppliers
4-Amino-3-fluoropyridine
(2247-88-3)
4 alternate names
3 suppliers
1,5-Naphthyridin-4-amine
(27392-68-3)
4 alternate names
3 suppliers
4-hydrazino-2-methylpyridine hydrobromide
(1301739-49-0)
4 alternate names
3 suppliers
quinoline-5,6-diamine
(42143-23-7)
4 alternate names
3 suppliers
quinoxalin-5-amine
(16566-20-4)
4 alternate names
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4,6-dichloropyridin-3-amine
(7321-93-9)
4 alternate names
3 suppliers
3-Hydrazinylquinoline
(15793-78-9)
4 alternate names
3 suppliers
4-Acetamidopyridine
(5221-42-1)
4 alternate names
3 suppliers
3H-IMIDAZO[4,5-C]PYRIDIN-7-AMINE
(792138-97-7)
4 alternate names
3 suppliers
2-AMINOPYRIDINE
(504-29-0, 24843-39-8, 26445-05-6)
4 alternate names
3 safety hazards
3 suppliers
2,4,6-trimethylpyridin-3-amine
(51467-70-0)
4 alternate names
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N~2~-phenylpyridine-2,5-diamine
(4928-44-3)
4 alternate names
3 suppliers
N-Octylpyridin-4-amine
(64690-19-3)
4 alternate names
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N~2~-isopropyl-2,5-pyridinediamine
(52025-41-9)
4 alternate names
3 suppliers
ethyl pyridin-3-ylcarbamate
(6276-11-5)
4 alternate names
3 suppliers
acridine-3,6-diamine hydrochloride
(7459-75-8, 952-23-8)
4 alternate names
3 suppliers
Phenazopyridine hydrochloride
(136-40-3)
4 alternate names
3 safety hazards
3 suppliers
1H-indol-3-amine
(7250-19-3)
4 alternate names
3 suppliers
4-Amino-3,5-dichloropyridine
(22889-78-7)
4 alternate names
3 suppliers
3,4-DIAMINOPYRIDINE
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