| Weight | 152.149 g/mol |
|---|---|
| Formula | C8H8O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
3,4-Dihydroxyphenylacetaldehyde (5707-55-1)
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- Sigma-Aldrich - Search for 3,4-Dihydroxyphenylacetaldehyde
- Fisher Scientific - Search for 3,4-Dihydroxyphenylacetaldehyde
- TCI - Search for 3,4-Dihydroxyphenylacetaldehyde
- Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase (Pharmacological Reviews, 2007)
- 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. (Brain Research, 2003)
- Enzymology and subcellular localization of aldehyde oxidation in rat liver. Oxidation of 3,4-dihydroxyphenylacetaldehyde derived from dopamine to 3,4-dihydroxyphenylacetic acid. (Biochemical Pharmacology, 1981)
- Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria (Free Radical Biology and Medicine, 2001)
- 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells (Brain Research, 2000)
- Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde (Journal of Neuroscience Research, 2000)
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SMILESC1=CC(=C(C=C1CC=O)O)O
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InChIKeyIADQVXRMSNIUEL-UHFFFAOYSA-N
- Pubchem - 3,4-Dihydroxyphenylacetaldehyde
- Wikipedia - 3,4-dihydroxyphenylacetaldehyde
3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an important metabolite of the major brain neurotransmitter, dopamine. All of the enzymatic metabolism of dopamine in neurons passes through DOPAL. According to the "catecholaldehyde hypothesis," DOPAL plays a role in the pathogenesis of Parkinson's disease.
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