| Weight | 387.523 g/mol |
|---|---|
| Formula | C26H29NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
4-Hydroxytamoxifen (65213-48-1, 68047-06-3)
Score:
#39 in Molecular and cellular biology
,
#1226 in Biochemistry
,
#3827 in Chemistry
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- Sigma-Aldrich - 4-Hydroxytamoxifen129.50 - 476.50 USD
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- Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. (The EMBO Journal, 1990)
- Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen (Molecular Endocrinology, 1997)
- 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma. (Proceedings of the National Academy of Sciences of the United States of America, 2001)
- Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans -4-Hydroxytamoxifen (Journal of the National Cancer Institute, 1991)
- 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30. (Molecular Pharmacology, 2006)
- Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. (Drug Metabolism and Disposition, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
-
InChIKeyTXUZVZSFRXZGTL-UHFFFAOYSA-N
- Pubchem - 4-Hydroxytamoxifen
- Wikipedia - hydroxytamoxifen
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome.
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