868-54-2 (868-54-2)

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  10 g
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Most-cited Publications

• THE ACTION OF 1,1,3-TRICYANO-2-AMINO-1-PROPENE (U-9189) ON THE THYROID GLAND OF THE RAT AND ITS EFFECTS IN HUMAN THYROTOXICOSIS* (The Journal of Clinical Endocrinology and Metabolism, 1961)
• 1,1,3-tricyano-2-amino-1-propene (U-9189), a biologically-active component of aqueous solutions of malononitrile (Biochemical and Biophysical Research Communications, 1960)
• 1,1,3 Tricyano-2-amino-1-propene (Triap): a small molecule which mimics or potentiates nerve growth factor (Developmental Brain Research, 1990)
• 1,1,3-Tricyano-2-amino-1-propene: specific reagent for fluorometric determination of copper in micro amounts (Analytical Chemistry, 1969)
• SYNTHESIS OF RNA IN VITRO STIMULATED IN DIPTERAN SALIVARY GLANDS BY 1,1,3-TRICYANO-2-AMINO-1-PROPENE. (Science, 1964)
• Effect of 1,1,3-tricyano-2-amino-1-propene on 2,3-cyclic AMP 3-phosphohydrolase in the sciatic nerve of the chick embryo (Biochimica et Biophysica Acta, 1972)

Areas of Application

Safety

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Trends

Alternate Names

• U-9189
• 1,1,3-tricyano-2-amino-1-propene
• Malononitrile dimer
• TRIAP
• SMILES
  C(C#N)C(=C(C#N)C#N)N
• InChIKey
  BNHGNFYPZNDLAF-UHFFFAOYSA-N

External Links

• Pubchem - 868-54-2
• Wikipedia - 2-amino-1-propene-1,1,3-tricarbonitrile
  Tricyanoaminopropene (TRIAP, TCAP, Malononitrile Dimer, 1,1,3-tricyano-2-amino-1-propene) is a nootropic drug which mimics the function of nerve growth factor and increases the growth of nerves and tissue regeneration both in isolated tissues and in vivo. It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production. This then results in increased synthesis of RNA in many different tissues in the body.

Synthesis

(Aminomethylene)malononitrile  +  CHLOROACETONITRILE (Heck non-terminal vinyl)

Synthesis of 868-54-2 ›

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