| Weight | 293.41 g/mol |
|---|---|
| Formula | C20H23NO |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Amitriptylinoxide (4290-60-2, 4317-14-0)
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- Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tensiontype headache: a multicentre controlled study (Cephalalgia, 1994)
- The Metabolic Fate of Amitriptyline, Nortriptyline and Amitriptylinoxide in Man (Drug Metabolism Reviews, 2004)
- Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen. (Drug Research, 2011)
- The metabolic fate of the antidepressive agent amitriptylinoxide in man. (Drug Research, 1978)
- Urinary metabolites of amitriptylinoxide and amitriptyline in single-dose experiments and during continuous therapy. (Psychopharmacology, 1992)
- Amitriptylinoxide: receptor-binding profile compared with other antidepressant drugs. (Pharmacopsychiatry, 1985)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC[N+](C)(CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31)[O-]
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InChIKeyZPMKQFOGINQDAM-UHFFFAOYSA-N
- Pubchem - Amitriptylinoxide
- Wikipedia - amitriptylinoxide
Amitriptylinoxide (brand names Amioxid, Ambivalon, Equilibrin), or amitriptyline N-oxide, is a tricyclic antidepressant (TCA) which was introduced in Europe in the 1970s for the treatment of depression. Amitriptylinoxide is both an analogue and metabolite of amitriptyline, and has similar effects as well as equivalent efficacy as an antidepressant. However, it has a faster onset of action and fewer adverse effects, including reduced drowsiness, sedation, anticholinergic symptoms like dry mouth, sweating, and dizziness, orthostatic hypotension, and cardiotoxicity.
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