| Weight | 283.331 g/mol |
|---|---|
| Formula | C16H17N3O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Amonafide (69408-81-7)
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- Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan. (Drug Metabolism and Disposition, 2001)
- New analogues of amonafide and elinafide, containing aromatic heterocycles: Synthesis, antitumor activity, molecular modeling, and DNA binding properties (Journal of Medicinal Chemistry, 2004)
- Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs. (Molecular Pharmacology, 1989)
- Paradoxical relationship between acetylator phenotype and amonafide toxicity (Clinical Pharmacology & Therapeutics, 1991)
- R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II. (Molecular Cancer Therapeutics, 2007)
- Phase I Study of Amonafide Dosing Based on Acetylator Phenotype (Cancer Research, 1993)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N
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InChIKeyUPALIKSFLSVKIS-UHFFFAOYSA-N
- Pubchem - Amonafide
- Wikipedia - amonafide
Amonafide (originally AS1413) (INN, trade names Quinamed and Xanafide) is a drug that is being studied in the treatment of cancer. It belongs to a novel family of chemotherapeutic drugs called Naphthalimides and is a potential topoisomerase inhibitor and DNA intercalator. It is being developed as an anti-cancer therapy by Antisoma.
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