| Weight | 265.309 g/mol |
|---|---|
| Formula | C14H19NO4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
anisomycin (22862-76-6)
Flagecidin
Score:
#744 in Neuroscience
,
#1360 in Biochemistry
,
#3294 in Biology
,
#4112 in Chemistry
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- Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro (Brain Research, 1988)
- Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats (Brain Research Bulletin, 1984)
- Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. (Molecular and Cellular Biology, 1994)
- Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- Inhibitors of Protein Biosynthesis II. MODE OF ACTION OF ANISOMYCIN (Journal of Biological Chemistry, 1967)
- Two sensitive periods for the amnesic effect of anisomycin (Pharmacology, Biochemistry and Behavior, 1980)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Flagecidin
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SMILESCC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O
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InChIKeyYKJYKKNCCRKFSL-UHFFFAOYSA-N
- Pubchem - anisomycin
- Wikipedia - anisomycin
Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
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anisomycin
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