| Weight | 213.664 g/mol |
|---|---|
| Formula | C10H12ClNO2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
baclofen (62594-36-9, 1134-47-0)
Lioresal · Genpharm · beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Score:
#87 in Neurology
,
#436 in Neuroscience
,
#2000 in Biology
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- Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor (Nature, 1980)
- 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain. (Nature, 1981)
- Letter: Baclofen in the treatment of schizophrenia. (The Lancet, 1975)
- Intrathecal baclofen for severe spinal spasticity (The New England Journal of Medicine, 1989)
- Studies in the Primate on the Analgetic Effects Associated with Intrathecal Actions of Opiates,-Adrenergic Agonists and Baclofen (Anesthesiology, 1981)
- Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro (The Journal of Physiology, 1992)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Lioresal
- Genpharm
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
- CIBA34,647BA
- PMS-Baclofen
- Apo Baclofen
- Ba-34647
- CIBA-34,647-BA
- Chlorophenyl GABA
- Clofen
- Atrofen
- Ba34,647
- Baclofen AWD
- ApoBaclofen
- Lebic
- GenBaclofen
- Ba-34,647
- Gen Baclofen
- Baclophen
- PMSBaclofen
- Baclofne Irex
- PCP-GABA
- Nu Baclo
- Apo-Baclofen
- Ba34647
- Baclospas
- Liorsal
- BaclofneIrex
- Baclofne-Irex
- NuBaclo
- PMS Baclofen
- Gen-Baclofen
- Nu-Baclo
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
-
SMILESC1=CC(=CC=C1C(CC(=O)O)CN)Cl
-
InChIKeyKPYSYYIEGFHWSV-UHFFFAOYSA-N
- Pubchem - baclofen
- Wikipedia - baclofen
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity. It is used as a central nervous system depressant and skeletal muscle relaxant although its effectiveness has not been clearly shown. It is also used in topical creams to help with pain.
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Most-cited Publications
Areas of Application
Safety
Trends
Alternate Names
External Links
Synthesis
CHLOROBENZENE
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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baclofen
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