| Weight | 388.895 g/mol |
|---|---|
| Formula | C21H25ClN2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 8 |
Bepotastine (125602-71-3)
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- Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11Cdoxepin (British Journal of Clinical Pharmacology, 2008)
- Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance (Clinical and Experimental Dermatology, 2004)
- Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate (Drug Metabolism and Disposition, 2006)
- Time to onset and duration of action of the antihistamine bepotastine besilate ophthalmic solutions 1.0% and 1.5% in allergic conjunctivitis: A phase III, single-center, prospective, randomized, double-masked, placebo-controlled, conjunctival allergen challenge assessment in adults and children (Clinical Therapeutics, 2009)
- Suppression by bepotastine besilate of substance P-induced itch-associated responses through the inhibition of the leukotriene B4 action in mice (European Journal of Pharmacology, 2006)
- Bepotastine besilate, a highly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models (Experimental Eye Research, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O
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InChIKeyYWGDOWXRIALTES-UHFFFAOYSA-N
- Pubchem - Bepotastine
- Wikipedia - bepotastine
Bepotastine (Talion, Bepreve) is a 2nd generation antihistamine. It was approved in Japan for use in the treatment of allergic rhinitis and urticaria/pruritus in July 2000 and January 2002, respectively. It is currently marketed in the United States under the brand-name Bepreve, by ISTA Pharmaceuticals.
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