| Weight | 173.259 g/mol |
|---|---|
| Formula | C12H15N |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
BICIFADINE (66504-75-4, 71195-57-8)
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- A method for the prediction of the crystal structure of ionic organic compoundsthe crystal structures of o-toluidinium chloride and bromide and polymorphism of bicifadine hydrochloride (CrystEngComm, 2004)
- Characterization of the Antinociceptive Actions of Bicifadine in Models of Acute, Persistent, and Chronic Pain (Journal of Pharmacology and Experimental Therapeutics, 2007)
- Stereocontrolled Synthesis of Trisubstituted Cyclopropanes: Expedient, Atom-Economical, Asymmetric Syntheses of (+)-Bicifadine and DOV21947 (ChemInform, 2006)
- The oral analgesic efficacy of bicifadine hydrochloride in postoperative pain. (The Journal of Clinical Pharmacology, 1982)
- Pharmacokinetics, Disposition, and Metabolism of Bicifadine in Humans (Drug Metabolism and Disposition, 2008)
- Determination of the Polymorphic Forms of Bicifadine Hydrochloride by Differential Scanning CalorimetryThermogravimetric Analysis, X-ray Powder Diffraction, Attenuated Total ReflectanceInfrared Spectroscopy, and Attenuated Total ReflectanceNear-Infrared Spectroscopy (Applied Spectroscopy, 2005)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC=C(C=C1)C23CC2CNC3
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InChIKeyOFYVIGTWSQPCLF-UHFFFAOYSA-N
- Pubchem - BICIFADINE
- Wikipedia - Bicifadine
Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth. In January 2007, Dov licensed the rights to bicifadine to XTL Biopharmaceuticals after bicifadine failed in a Phase III clinical trial for chronic lower back pain. XTL ran a PhaseIIb clinical trial for pain caused by diabetic neuropathy, which failed in 2008; XTL terminated the agreement in 2010.
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Synthesis
Reactant
+
2-(4-methylphenyl)propan-1-amine
(Reductive amination)
Similar Compounds
Biphenyl
(92-52-4, 68409-73-4)
1 alternate name
6 safety hazards
3 suppliers
4-tert-Butyltoluene
(98-51-1)
1 alternate name
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CRESYL GLYCIDYL ETHER
(26447-14-3, 2186-24-5)
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4-METHOXYBIPHENYL
(613-37-6)
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2-Phenylphenol
(61788-42-9, 90-43-7)
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P-CYMENE
(99-87-6, 4939-75-7, 25155-15-1)
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2 safety hazards
3 suppliers
Diphenyl oxide
(101-84-8)
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Diphenylamine
(68442-68-2, 122-39-4)
1 alternate name
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Diphenylmethane
(101-81-5)
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1,6-DIMETHYLNAPHTHALENE
(575-43-9)
1 alternate name
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2-Aminobiphenyl
(90-41-5)
1 alternate name
4 safety hazards
3 suppliers
2-(4-methylphenyl)propan-2-ol
(1197-01-9)
1 alternate name
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p-Cymen-8-ol
(1197-01-9)
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1195-32-0
(1195-32-0)
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(645-59-0)
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2-Fluorobiphenyl
(321-60-8)
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DICYCLOPENTADIENE
(1755-01-7, 77-73-6, 25038-78-2)
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10 safety hazards
3 suppliers
cinnamaldehyde
(14371-10-9, 104-55-2, 57194-69-1)
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3 suppliers
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(532-27-4)
1 alternate name
3 safety hazards
3 suppliers
3-phenylprop-2-enal
(104-55-2)
1 alternate name
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2-Propenal, 3-phenyl-
(104-55-2)
1 alternate name
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1,2-DIPHENYLHYDRAZINE
(122-66-7, 38622-18-3)
1 alternate name
5 safety hazards
3 suppliers
N,N-Dimethyl-p-toluidine
(99-97-8)
1 alternate name
6 safety hazards
3 suppliers
2-CHLOROBIPHENYL
(27323-18-8, 11097-69-1, 2051-60-7, 53469-21-9)
1 alternate name
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Benzal chloride
(98-87-3, 29797-40-8)
1 alternate name
7 safety hazards
3 suppliers
1-CHLORONAPHTHALENE
(25586-43-0, 90-13-1)
1 alternate name
4 safety hazards
3 suppliers
4-Methylstyrene
(622-97-9, 1319-73-9, 24936-41-2)
1 alternate name
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3-Phenylpropan-1-ol
(1335-12-2, 122-97-4, 93842-54-7)
1 alternate name
3 suppliers
Phenylacetonitrile
(140-29-4)
1 alternate name
3 safety hazards
3 suppliers
BENZYL CHLOROFORMATE
(501-53-1)
1 alternate name
3 safety hazards
3 suppliers
Estragole
(140-67-0)
1 alternate name
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CARVACROL
(499-75-2)
1 alternate name
3 suppliers
ALPHA-PHELLANDRENE
(4221-98-1, 1329-99-3, 99-83-2, 34448-33-4)
1 alternate name
3 suppliers
cinnamyl alcohol
(4407-36-7, 104-54-1)
1 alternate name
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CINNAMIC ACID
(621-82-9, 9045-22-1, 140-10-3, 63938-16-9)
1 alternate name
3 suppliers
DIPHENYL DISULFIDE
(882-33-7)
1 alternate name
2 safety hazards
3 suppliers
2-[(2-Methylphenoxy)methyl]oxirane
(2210-79-9)
1 alternate name
2 safety hazards
3 suppliers
ALPHA-TERPINENE
(99-86-5)
1 alternate name
3 suppliers
METHYL 4-METHYLBENZOATE
(99-75-2)
1 alternate name
3 suppliers
6-METHYLQUINOLINE
(91-62-3)
1 alternate name
3 suppliers
Phenyl disulfide
(882-33-7)
1 alternate name
2 safety hazards
3 suppliers
4-Methoxycinnamic acid
(943-89-5, 830-09-1)
1 alternate name
3 suppliers
PHENYLACETYL CHLORIDE
(103-80-0)
1 alternate name
3 suppliers
4'-Methylacetophenone
(122-00-9)
1 alternate name
1 safety hazard
3 suppliers
4'-Methylacetanilide
(103-89-9)
1 alternate name
3 suppliers
p-Tolunitrile
(104-85-8)
1 alternate name
3 suppliers
3-Phenylpropanal
(104-53-0, 1335-10-0)
1 alternate name
3 suppliers
5-Methoxytryptophol
(712-09-4)
1 alternate name
3 suppliers
Phenethyl isocyanate
(1943-82-4)
1 alternate name
4 safety hazards
3 suppliers
2-Amino-1-phenylethanol
(4561-43-7, 7568-93-6)
1 alternate name
3 suppliers
5-METHOXYTRYPTAMINE
(608-07-1)
1 alternate name
3 suppliers
Z-cinnamyl alcohol
(104-54-1, 4510-34-3)
1 alternate name
3 suppliers
4-Methylbenzyl chloride
(104-82-5, 57030-73-6)
1 alternate name
1 safety hazard
3 suppliers
6-tert-Butyl-m-cresol
(88-60-8)
1 alternate name
5 safety hazards
3 suppliers
2-chloro-N-(4-methylphenyl)acetamide
(16634-82-5)
1 alternate name
3 safety hazards
3 suppliers
1,2-Diphenylethane
(103-29-7, 38888-98-1)
1 alternate name
3 suppliers
p-Tolyl acetate
(140-39-6)
1 alternate name
3 suppliers
2-(Benzyloxy)ethanol
(622-08-2)
1 alternate name
1 safety hazard
3 suppliers
Thymol methyl ether
(1076-56-8)
1 alternate name
3 suppliers
Benzyl thiocyanate
(3012-37-1)
1 alternate name
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Phenylpropiolic acid
(637-44-5)
1 alternate name
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Dipentene
(7705-14-8, 9003-73-0, 8008-56-8, 65996-98-7, 8008-57-9, 138-86-3, 8028-38-4, 0008008-57-9)
1 alternate name
4 safety hazards
3 suppliers
naphthalene
(91-20-3, 68412-25-9)
1 alternate name
7 safety hazards
3 suppliers
P-XYLENE
(68650-36-2, 68411-39-2, 106-42-3)
1 alternate name
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BENZYL CHLORIDE
(100-44-7, 25168-05-2)
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13 safety hazards
3 suppliers
D-Limonene
(5989-27-5, 68606-81-5, 5989-27-5, 65996-98-7)
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(95-63-6)
1 alternate name
5 safety hazards
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p-Toluidine
(26915-12-8, 106-49-0)
1 alternate name
8 safety hazards
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Quinoline
(91-22-5)
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2-METHYLNAPHTHALENE
(7419-61-6, 91-57-6)
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4-Aminobiphenyl
(92-67-1)
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BENZOTRICHLORIDE
(61878-57-7, 98-07-7, 30583-33-6)
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1-NAPHTHOL
(90-15-3, 1321-67-1)
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1-NAPHTHYLAMINE
(25168-10-9, 134-32-7)
1 alternate name
2 safety hazards
3 suppliers
BENZOYL CHLORIDE
(98-88-4)
1 alternate name
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3 suppliers
BENZONITRILE
(100-47-0)
1 alternate name
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alpha-TERPINEOL
(8000-41-7, 10482-56-1, 68797-63-7, 2438-12-2, 98-55-5)
1 alternate name
3 suppliers
azobenzene
(103-33-3, 17082-12-1, 1080-16-6)
1 alternate name
6 safety hazards
3 suppliers
METHYLEUGENOL
(93-15-2)
1 alternate name
3 safety hazards
3 suppliers
2-Methoxy-5-methylaniline
(120-71-8)
1 alternate name
3 safety hazards
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4-Chlorotoluene
(3327-51-3, 106-43-4)
1 alternate name
5 safety hazards
3 suppliers
DICYCLOHEXYLAMINE
(101-83-7)
1 alternate name
8 safety hazards
3 suppliers
p-Tolualdehyde
(104-87-0)
1 alternate name
3 safety hazards
3 suppliers
2,4-DICHLOROTOLUENE
(95-73-8)
1 alternate name
3 safety hazards
3 suppliers
1,4-DIETHYLBENZENE
(10565-77-2, 105-05-5)
1 alternate name
3 safety hazards
3 suppliers
2-Methyl-5-vinylpyridine
(140-76-1)
1 alternate name
3 suppliers
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