| Weight | 459.558 g/mol |
|---|---|
| Formula | C26H34FNO5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 11 |
cerivastatin (145599-86-6, 143201-11-0)
Score:
#11 in Molecular and cellular biology
,
#467 in Biochemistry
,
#1497 in Biology
,
#1758 in Chemistry
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- Cerivastatin and Reports of Fatal Rhabdomyolysis (The New England Journal of Medicine, 2002)
- An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and Tissue Factor In Vivo and In Vitro (Circulation, 2001)
- Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia. (Circulation, 2001)
- Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil (Journal of Pharmacology and Experimental Therapeutics, 2004)
- Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A (Journal of Pharmacology and Experimental Therapeutics, 2003)
- Gemfibrozil greatly increases plasma concentrations of cerivastatin. (Clinical Pharmacology & Therapeutics, 2002)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)C1=C(C(=C(C(=N1)C(C)C)C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)COC
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InChIKeySEERZIQQUAZTOL-UHFFFAOYSA-N
- Pubchem - cerivastatin
- Wikipedia - cerivastatin
Cerivastatin (INN, brand names: Baycol, Lipobay) is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s, competing with Pfizer's highly successful atorvastatin (Lipitor).
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Synthesis
1-Bromo-4-fluorobenzene
+
Reactant
(Stille)
Reactant
+
1-Chloro-4-fluorobenzene
(Suzuki)
Reactant
+
1-Chloro-4-fluorobenzene
(Decarboxylative coupling)
Reactant
+
1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide
(Nicolaou IBX dehydrogenation)
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