| Weight | 370.792 g/mol |
|---|---|
| Formula | C19H15ClN2O4 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 5 |
rebamipide (90098-04-7)
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- Hydroxyl radical scavenging by rebamipide and related compounds: Electron paramagnetic resonance study (Free Radical Biology and Medicine, 1995)
- Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats (Digestive Diseases and Sciences, 1993)
- Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. (Digestive Diseases and Sciences, 1998)
- Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects : a prospective, randomized, double-blinded, placebo-controlled, cross-over study (Journal of Gastroenterology, 2008)
- Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. (Gut, 1994)
- Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats (European Journal of Pharmacology, 1992)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
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InChIKeyALLWOAVDORUJLA-UHFFFAOYSA-N
- Pubchem - rebamipide
- Wikipedia - rebamipide
Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2. Rebamipide is used in a number of Asian countries including Japan (marketed as Mucosta), South Korea, China and India (where it is marketed under the trade name Rebagen).
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Synthesis
2-Hydroxyquinoline
+
Reactant
(Friedel-Crafts alkylation)
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rebamipide
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