| Weight | 409.423 g/mol |
|---|---|
| Formula | C22H23F4NO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
Trifluperidol (749-13-3)
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- The evolution of the butyrophenones, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines. (International Review of Neurobiology, 1965)
- Sila-Trifluperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Trifluperidol: Synthesis and Pharmacological Characterization (Organometallics, 2010)
- Characterization of Haloperidol and Trifluperidol as Subtype-Selective N-Methyl-d-Aspartate (NMDA) Receptor Antagonists Using [3H]TCP and [3H]Ifenprodil Binding in Rat Brain Membranes (Journal of Pharmacology and Experimental Therapeutics, 1997)
- Flupentixol and trifluperidol reduce secretion of tumor necrosis factor- and nitric oxide by rat microglial cells (Neurochemistry International, 2003)
- Comparison of trifluperidol, trifluoperazine and chlorpromazine in preschool schizophrenic children: the value of less sedative antipsychotic agents. (Current Therapeutic Research-clinical and Experimental, 1969)
- The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity. (Drug Research, 1969)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CN(CCC1(C2=CC(=CC=C2)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F
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InChIKeyGPMXUUPHFNMNDH-UHFFFAOYSA-N
- Pubchem - Trifluperidol
- Wikipedia - trifluperidol
Trifluperidol is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the treatment of psychoses including mania and schizophrenia.
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