| Weight | 395.478 g/mol |
|---|---|
| Formula | C23H26FN3O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
spiperone (749-02-0)
Spiroperidol · Spiroperone
Score:
#931 in Neuroscience
,
#4086 in Biology
,
#5152 in Chemistry
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- Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol (Molecular Pharmacology, 1979)
- Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding (Science, 1980)
- Discrimination of Multiple [3H]5Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain (Journal of Neurochemistry, 1981)
- Spiperone: A ligand of choice for neuroleptic receptors: 1. Kinetics and characteristics of in vitro binding (Biochemical Pharmacology, 1978)
- 3H-Spiroperidol labels dopamine receptors in pituitary and brain. (European Journal of Pharmacology, 1977)
- Distribution of dopaminergic receptors in the primate cerebral cortex : quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390 (Neuroscience, 1991)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Spiroperidol
- Spiroperone
-
SMILESC1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(=O)C4=CC=C(C=C4)F
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InChIKeyDKGZKTPJOSAWFA-UHFFFAOYSA-N
- Pubchem - spiperone
- Wikipedia - spiperone
Spiperone (Spiroperidol; brand name: Spiropitan (JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class. It is licensed for clinical use in Japan as a treatment for schizophrenia. Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl channels (CaCCs), thus a potential target for therapy of cystic fibrosis.
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spiperone
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