| Weight | 303.681 g/mol |
|---|---|
| Formula | C10H11ClFN5O3 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
Clofarabine (123318-82-1)
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- Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia (Blood, 2003)
- Phase II Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia (Journal of Clinical Oncology, 2006)
- Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia (Blood, 2003)
- Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias (Blood, 2004)
- DNA Repair Initiated in Chronic Lymphocytic Leukemia Lymphocytes by 4-Hydroperoxycyclophosphamide Is Inhibited by Fludarabine and Clofarabine (Clinical Cancer Research, 2001)
- A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome (Blood, 2008)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl
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InChIKeyWDDPHFBMKLOVOX-UHFFFAOYSA-N
- Pubchem - Clofarabine
- Wikipedia - clofarabine
Clofarabine is a purine nucleoside antimetabolite marketed in the US and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra. It is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed.
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