Weight | 199.637 g/mol |
---|---|
Formula | C9H10ClNO2 |
Hydrogen Acceptors | 2 |
Hydrogen Donors | 2 |
Aromatic Rings | 1 |
Rotatable Bonds | 3 |
Fenclonine (1991-78-2, 7424-00-2)
Fenclonine (L)-Isomer · Fenclonine Hydrobromide · Fenclonine, (D)-Isomer
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- Sigma-Aldrich - Fenclonine101.50 - 386.00 USD
- Fisher Scientific - Search for Fenclonine
- TCI - Fenclonine26.00 - 241.00 USD
- Clinical and biochemical effects of fenclonine: a serotonin depletor. (Diseases of the nervous system, 1968)
- Does fenclonine open up new perspectives in the treatment of impotence (Lijecnicki vjesnik, 1975)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Fenclonine (L)-Isomer
- Fenclonine Hydrobromide
- Fenclonine, (D)-Isomer
- CP-10,188
- Fenclonin
- p-Chlorophenylalanine
- DL-3-(4-Chlorophenyl)alanine
- Fenclonine Hydrochloride
- para-Chlorophenylalanine
- para Chlorophenylalanine
-
SMILESC1=CC(=CC=C1CC(C(=O)O)N)Cl
-
InChIKeyNIGWMJHCCYYCSF-UHFFFAOYSA-N
- Pubchem - Fenclonine
- Wikipedia - fenclonine
Fenclonine, also known as para-chlorophenylalanine (PCPA), acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin. It has been used experimentally to treat carcinoid syndrome, but the side effects, mostly hypersensitivity reactions and psychiatric disturbances, have prevented development for this use. The effects of serotonin depletion from fenclonine are so drastic that serotonin cannot even be detected immunohistochemically within the first day after administration of a control dose.
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