Clomethiazole (533-45-9)

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Suppliers

• Sigma-Aldrich - Search for Clomethiazole
• Fisher Scientific - Search for Clomethiazole
• TCI - Search for Clomethiazole

Most-cited Publications

• Clomethiazole Acute Stroke Study (CLASS) Results of a Randomized, Controlled Trial of Clomethiazole Versus Placebo in 1360 Acute Stroke Patients (Stroke, 1999)
• Clomethiazole Acute Stroke Study in Ischemic Stroke (CLASS-I) Final Results (Stroke, 2002)
• 5HT loss in rat brain following 3, 4methylenedioxymethamphetamine (MDMA), pchloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine (British Journal of Pharmacology, 1993)
• Inhibition of Ethanol-Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole (Experimental Biology and Medicine, 2000)
• Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil (British Journal of Pharmacology, 1991)
• Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA (Ecstasy) to rats (Neuropharmacology, 1994)

Areas of Application

Safety

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Trends

Alternate Names

• Chlormethiazole
• Distraneurin
• SMILES
  CC1=C(SC=N1)CCCl
• InChIKey
  PCLITLDOTJTVDJ-UHFFFAOYSA-N

External Links

• Pubchem - Clomethiazole
• Wikipedia - clomethiazole
  Clomethiazole (also called chlormethiazole) is a sedative and hypnotic originally developed by Hoffmann-La Roche in the 1930s. The drug is used in treating and preventing symptoms of acute alcohol withdrawal. It is structurally related to thiamine (vitamin B1), but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant, having the same mechanism of action as traditional barbiturates..

Synthesis

4-METHYLTHIAZOLE  +  1,2-dichloroethane (Friedel-Crafts alkylation)

Synthesis of Clomethiazole ›

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Clomethiazole

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