| Weight | 364.441 g/mol |
|---|---|
| Formula | C23H24O4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
cyclofenil (2624-43-3)
Cyclophenil · F 6066 · Ondogyne
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- Retrograde trafficking of both Golgi complex and TGN markers to the ER induced by nordihydroguaiaretic acid and cyclofenil diphenol (Journal of Cell Science, 1998)
- Fluorine-Substituted Cyclofenil Derivatives as Estrogen Receptor Ligands: Synthesis and Structure-Affinity Relationship Study of Potential Positron Emission Tomography Agents for Imaging Estrogen Receptors in Breast Cancer (Journal of Medicinal Chemistry, 2006)
- Effect of cyclofenil on hormonal dynamics, follicular development and cervical mucus in normal and oligomenorrhoeic women (Human Reproduction, 1992)
- Cyclofenil versus Placebo in Progressive Systemic Sclerosis: A One-Year Double-Blind Crossover Study of 27 Patients (Acta Medica Scandinavica, 2009)
- A prospective, randomised, cross-over study comparing the effects of clomiphene citrate and cyclofenil on endometrial morphology in the luteal phase of normal, fertile women (British Journal of Obstetrics and Gynaecology, 1992)
- CYCLOFENIL TREATMENT OF SCLERODERMAA CONTROLLED STUDY (Rheumatology, 1983)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Cyclophenil
- F 6066
- Ondogyne
- F6066
- 4-((4-(Acetyloxy)phenyl)cyclohexylidenemethyl)phenol Acetate
- F-6066
-
SMILESCC(=O)OC1=CC=C(C=C1)C(=C2CCCCC2)C3=CC=C(C=C3)OC(=O)C
-
InChIKeyGVOUFPWUYJWQSK-UHFFFAOYSA-N
- Pubchem - cyclofenil
- Wikipedia - cyclofenil
Cyclofenil (INN, USAN, BAN) (brand names Fertodur, Menopax, Ondonid, Ondogyne, Sexovid, others) is a selective estrogen receptor modulator (SERM) used as a gonadotropin stimulant which is or has been marketed in Europe, South Korea, Mexico, and Brazil, among other countries. Cyclofenil was first introduced in 1970 under the brand name Ondogyne in France. Subsequently, it was introduced under the brand names Sexovid in Japan in 1972, Ondonvid in the United Kingdom in 1972, and Fertodur in West Germany in 1972 and Italy in 1974.
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Synthesis
Reactant
+
4-Chlorophenyl acetate
(Stille)
Reactant
+
4-Chlorophenyl acetate
(Heck non-terminal vinyl)
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cyclofenil
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