diethyl pyrocarbonate (1609-47-8)

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  100 g
  $108.00

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Most-cited Publications

• [41] Modification of histidyl residues in proteins by diethylpyrocarbonate (Methods in Enzymology, 1977)
• Ethoxyformylation of proteins. Reaction of ethoxyformic anhydride with alpha-chymotrypsin, pepsin, and pancreatic ribonuclease at pH 4. (Biochemistry, 1970)
• A New Method Based on the Use of Diethyl Pyrocarbonate as a Nuclease Inhibitor for the Extraction of Undegraded Nucleic Acid from Plant Tissues (FEBS Journal, 1968)
• A simle method for extraction of RNA from E. coli utilizing diethyl pyrocarbonate (Analytical Biochemistry, 1970)
• Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting. (Journal of Biological Chemistry, 2002)
• Diethylpyrocarbonate, a vapour-phase fixative for immunofluorescence studies on polypeptide hormones. (Histochemical Journal, 1974)

Areas of Application

Safety

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Trends

Alternate Names

• Diethylpyrocarbonate
• Ethoxyformic Anhydride
• Diethyl Dicarbonate
• Diethyl Oxydiformate
• Pyrocarbonic Acid Diethyl Ester
• SMILES
  CCOC(=O)OC(=O)OCC
• InChIKey
  FFYPMLJYZAEMQB-UHFFFAOYSA-N

External Links

• Pubchem - diethyl pyrocarbonate
• Wikipedia - diethyl pyrocarbonate
  Diethyl pyrocarbonate (DEPC), also called diethyl dicarbonate (IUPAC name), is used in the laboratory to inactivate RNase enzymes in water and on laboratory utensils. It does so by the covalent modification of histidine (most strongly), lysine, cysteine, and tyrosine residues. DEPC-treated (and therefore RNase-free) water is used in handling of RNA in the laboratory to reduce the risk of RNA being degraded by RNases.

Synthesis

pyrocarbonic acid ethyl ester  +  Chloroethane (Ester from carboxilic acid(SN2))

Synthesis of diethyl pyrocarbonate ›

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(R)-(+)-Propylene carbonate (16606-55-6)

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2,2-Diethoxyethylamine (645-36-3)

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18669-04-0 (18669-04-0)

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10160-87-9 (10160-87-9)

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94158-44-8 (94158-44-8)

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2806-97-5 (2806-97-5)

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Isopentyl formate (110-45-2)

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Chloroacetic anhydride (541-88-8)

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DIBROMOACETALDEHYDE DIETHYL ACETAL (761-17-1)

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31224-45-0 (31224-45-0)

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3616-56-6 (3616-56-6)

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diethyl pyrocarbonate

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