Weight | 144.126 g/mol |
---|---|
Formula | C6H8O4 |
Hydrogen Acceptors | 4 |
Hydrogen Donors | 0 |
Aromatic Rings | 0 |
Rotatable Bonds | 2 |
Dimethyl fumarate (624-49-7, 23055-10-9)
BG-12 compound · BG 12 compound · Tecfidera
Score:
#108 in Neuroscience
,
#558 in Biology
,
#594 in Chemistry
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- Sigma-Aldrich - Dimethyl fumarate25.80 - 85.40 USD
- Fisher Scientific - Search for Dimethyl fumarate
- TCI - Dimethyl fumarate26.00 - 127.00 USD
- PML in a patient treated with dimethyl fumarate from a compounding pharmacy. (The New England Journal of Medicine, 2013)
- Growth of Campylobacter jejuni Supported by Respiration of Fumarate, Nitrate, Nitrite, Trimethylamine-N-Oxide, or Dimethyl Sulfoxide Requires Oxygen (Journal of Bacteriology, 2002)
- PML in a Patient with Lymphocytopenia Treated with Dimethyl Fumarate (The New England Journal of Medicine, 2015)
- Effects of dimethyl fumarate on neuroprotection and immunomodulation (Journal of Neuroinflammation, 2012)
- Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarates protective effect in EAE (Journal of Clinical Investigation, 2014)
- PML in a patient without severe lymphocytopenia receiving dimethyl fumarate. (The New England Journal of Medicine, 2015)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - BG-12 compound
- BG 12 compound
- Tecfidera
- BG00012
- BG12 compound
- FAG-201
- Fumaderm
- BG 00012
- Fumarate, Dimethyl
- 2-butenedioic acid, (2E)-, dimethyl ester
- FAG201
- BG-00012
- dimethylfumarate
- FAG 201
-
SMILESCOC(=O)C=CC(=O)OC
-
InChIKeyLDCRTTXIJACKKU-UHFFFAOYSA-N
- Pubchem - Dimethyl fumarate
- Wikipedia - dimethyl fumarate
Dimethyl fumarate (DMF) is the methyl ester of fumaric acid. DMF was initially recognized as a very effective hypoxic cell radiosensitizer. Later, DMF combined with three other fumaric acid esters (FAE) was licensed in Germany as oral therapy for psoriasis (trade name Fumaderm).
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Synthesis
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
Reactant
+
1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide
(Nicolaou IBX dehydrogenation)
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