| Weight | 221.303 g/mol |
|---|---|
| Formula | C16H15N |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 0 |
DIZOCILPINE (77086-21-6)
Score:
#171 in Neuroscience
,
#837 in Biology
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- Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex. (Experimental Neurology, 1993)
- The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias (Brain Research Reviews, 1995)
- Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment (Brain Research, 1998)
- Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle (Biological Psychiatry, 1991)
- Behavioral evidence for a modulating role of ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia (Brain Research, 1994)
- Multiple Limbic Regions Mediate the Disruption of Prepulse Inhibition Produced in Rats by the Noncompetitive NMDA Antagonist Dizocilpine (The Journal of Neuroscience, 1998)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24
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InChIKeyLBOJYSIDWZQNJS-UHFFFAOYSA-N
- Pubchem - DIZOCILPINE
- Wikipedia - dizocilpine
Dizocilpine (INN), also known as MK-801, is an noncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor, a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the brain's primary excitatory neurotransmitter. The channel is normally blocked with a magnesium ion and requires depolarization of the neuron to remove the magnesium and allow the glutamate to open the channel, causing an influx of calcium, which then leads to subsequent depolarization.
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