| Weight | 173.259 g/mol |
|---|---|
| Formula | C12H15N |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
MPTP (28289-54-5)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine · N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Score:
#890 in Neuroscience
,
#3915 in Biology
,
#4928 in Chemistry
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- A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (Proceedings of the National Academy of Sciences of the United States of America, 1983)
- Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine (The Journal of Neuroscience, 2000)
- Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. (Proceedings of the National Academy of Sciences of the United States of America, 1985)
- The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. (Journal of Neurophysiology, 1994)
- Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. (Biochemical and Biophysical Research Communications, 1984)
- Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease (The Journal of Neuroscience, 2002)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
SMILESCN1CCC(=CC1)C2=CC=CC=C2
-
InChIKeyPLRACCBDVIHHLZ-UHFFFAOYSA-N
- Pubchem - MPTP
- Wikipedia - MPTP
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used to study disease models in various animal studies. While MPTP itself has no psychoactive effects, the compound may be accidentally produced during the manufacture of MPPP, a synthetic opioid drug with effects similar to those of morphine and pethidine (meperidine).
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