| Weight | 302.374 g/mol |
|---|---|
| Formula | C17H22N2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
Emivirine (149950-60-7)
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- Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. (Journal of Medicinal Chemistry, 1999)
- Synthesis of Novel N-1 (Allyloxymethyl) Analogues of 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, Emivirine) with Improved Activity Against HIV-1 and Its Mutants (Journal of Medicinal Chemistry, 2002)
- Safety Assessment, In Vitro and In Vivo, and Pharmacokinetics of Emivirine, a Potent and Selective Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1 (Antimicrobial Agents and Chemotherapy, 2000)
- Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine. (Bioorganic & Medicinal Chemistry, 2004)
- Synthesis and Evaluation of Double-Prodrugs against HIV. Conjugation of D4T with 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, Emivirine)-Type Reverse Transcriptase Inhibitors via the SATE Prodrug Approach (Journal of Medicinal Chemistry, 2005)
- Multiple pathways in the synthesis of new annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (emivirine) (Organic and Biomolecular Chemistry, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
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- Pubchem - Emivirine
- Wikipedia - emivirine
Emivirine (MKC-442) is a failed experimental agent for the treatment of HIV. It is a non-nucleoside reverse transcriptase inhibitor. While emivirine showed promising antiviral activity in vitro, it failed to show sufficient efficacy in human trials.
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