| Weight | 491.694 g/mol |
|---|---|
| Formula | C27H41NO5S |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
Epothilone D (189453-10-9)
Score:
#719 in Neuroscience
,
#1299 in Biochemistry
,
#3184 in Biology
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#3982 in Chemistry
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- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice (The Journal of Neuroscience, 2012)
- Epothilone D Improves Microtubule Density, Axonal Integrity and Cognition in a Transgenic Mouse Model of Tauopathy (The Journal of Neuroscience, 2010)
- Heterologous production of epothilone C and D in Escherichia coli (Biochemistry, 2006)
- Optimizing the heterologous production of epothilone D in Myxococcus xanthus (Biotechnology and Bioengineering, 2002)
- Crystal Structures of Epothilone D-bound, Epothilone B-bound, and Substrate-free Forms of Cytochrome P450epoK (Journal of Biological Chemistry, 2003)
- Total Synthesis of Epothilone B, Epothilone D, and cis- and trans-9,10-Dehydroepothilone D (Journal of the American Chemical Society, 2001)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C
-
InChIKeyXOZIUKBZLSUILX-UHFFFAOYSA-N
- Pubchem - Epothilone D
- Wikipedia - Epothilone
The epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials epothilones have better efficacy and milder adverse effects than taxanes. As of September 2008, epothilones A to F have been identified and characterised.
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