| Weight | 254.285 g/mol |
|---|---|
| Formula | C16H14O3 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
fenbufen (36330-85-5)
Lederfen · Cinopal · gamma-oxo(1,1'-biphenyl)-4-butanoic acid
Score:
#1593 in Physics
,
#3860 in Biology
,
#4860 in Chemistry
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- Inorganic layered double hydroxides as a drug delivery system: intercalation and in vitro release of fenbufen (Applied Clay Science, 2004)
- Fenbufen, a New Anti-Inflammatory Analgesic: Synthesis and Structure-Activity Relationships of Analogs (Journal of Pharmaceutical Sciences, 1977)
- Improved Dissolution Behavior of Fenbufen by Spherical Crystallization (Drug Development and Industrial Pharmacy, 1999)
- Quinolones and fenbufen interact with GABAA receptor in dissociated hippocampal cells of rat. (Journal of Neurophysiology, 1991)
- Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents (European Journal of Medicinal Chemistry, 2009)
- Disposition and metabolism of fenbufen in several laboratory animals. (Drug Research, 1980)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Lederfen
- Cinopal
- gamma-oxo(1,1'-biphenyl)-4-butanoic acid
-
SMILESC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CCC(=O)O
-
InChIKeyZPAKPRAICRBAOD-UHFFFAOYSA-N
- Pubchem - fenbufen
- Wikipedia - fenbufen
Fenbufen is a nonsteroidal anti-inflammatory drug in the propionic acid derivatives class. It was introduced by American Cyanamid under the trade name Lederfen in the 1980s and was withdrawn from markets in the developed world due to liver toxicity in 2010. As of 2015 it was available in Taiwan and Thailand under several brand names.
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Synthesis
Reactant
+
CHLOROBENZENE
(Suzuki)
Reactant
+
CHLOROBENZENE
(Decarboxylative coupling)
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methyl 4-(4-methoxyphenyl)-2,4-dioxobutanoate
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fenbufen
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