| Weight | 446.37 g/mol |
|---|---|
| Formula | C20H20BrN3O2S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
h-89 (127243-85-0)
Score:
#1662 in Physics
,
#4053 in Biology
,
#5108 in Chemistry
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- Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. (Journal of Biological Chemistry, 1990)
- Carcinogens and mutagens in the environment: Vol. 1. Food Products. H.F. Stich (Ed.), CRC Press Inc., Boca Raton, FL, U.S.A. (US$89.50; outside U.S., $99.50) (Cancer Letters, 1983)
- Pharmacological Inhibition of Protein Kinases in Intact Cells: Antagonism of Beta Adrenergic Receptor Ligand Binding by H-89 Reveals Limitations of Usefulness (Journal of Pharmacology and Experimental Therapeutics, 1999)
- Psychosocial Aspects of Pain: a Handbook for Health Care Providers. Progress in Pain Research and Management. Volume 27. R. H. Dworkin and W. S. Breitbart (editors). Published by IASP Press, Seattle. Pp. 664; indexed; illustrated. Price US$89.00. ISBN 0-931092-48-5. (BJA: British Journal of Anaesthesia, 2004)
- EVOLUTION OF MAGNETIC FIELDS IN HIGH MASS STAR FORMATION: SUBMILLIMETER ARRAY DUST POLARIZATION IMAGE OF THE ULTRACOMPACT H ii REGION G5.890.39 (The Astrophysical Journal, 2009)
- Synthetic allophane and layer-silicate formation in SiO 2 -Al 2 -O 3 -FeO-Fe 2 O 3 -MgO-H 2 O systems at 23 degrees C and 89 degrees C in a calcareous environment (Clays and Clay Minerals, 1991)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br
-
InChIKeyZKZXNDJNWUTGDK-UHFFFAOYSA-N
- Pubchem - h-89
- Wikipedia - H-89
H-89 is a protein kinase inhibitor with greatest effect on protein kinase A (PKA). H-89, derived from H-8 (N-[2-(methylamino)ethyl]-5-isoquinoline-sulfonamide), was initially believed to act specifically as an inhibitor of PKA , being 30 times more potent than H-8 at inhibiting PKA and 10 times less potent at inhibiting protein kinase G. It achieves this through competitive inhibition of the adenosine triphosphate (ATP) site on the PKA catalytic subunit.
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Synthesis
Isoquinoline-5-sulfonyl Chloride
+
Reactant
(Sulfonamide)
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