Hippuric acid (495-69-2)

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Most-cited Publications

• THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN (Journal of Clinical Investigation, 1945)
• Rapid Hippurate Hydrolysis Method for Presumptive Identification of Group B Streptococci (Journal of Clinical Microbiology, 1975)
• Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity (Xenobiotica, 1998)
• The Clinical Application of the Hippuric Acid and the Prothrombin Tests (American Journal of Clinical Pathology, 1940)
• Intertidal sediments as reservoirs for hippurate negative campylobacters, salmonellae and faecal indicators in three EU recognised bathing waters in North West England (Water Research, 2000)
• Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine (The American Journal of Clinical Nutrition, 2005)

Areas of Application

Safety

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Trends

Alternate Names

• hippurate
• benzoylglycine
• ammonium hippurate
• hippuric acid, monosodium salt
• benzamidoacetic acid
• hippuric acid, monoammonium salt
• hippuric acid, (14)C-labeled
• hippuric acid, monopotassium salt
• SMILES
  C1=CC=C(C=C1)C(=O)NCC(=O)O
• InChIKey
  QIAFMBKCNZACKA-UHFFFAOYSA-N

External Links

• Pubchem - Hippuric acid
• Wikipedia - hippuric acid
  Hippuric acid (Gr. hippos, horse, ouron, urine) is a carboxylic acid found in the urine of horses and other herbivores. Hippuric acid crystallizes in rhombic prisms which are readily soluble in hot water, melt at 187 C, and decompose at about 240 C.

Synthesis

Benzamide  +  chloroacetic acid (Alkylation of primary amines)

BENZOYL CHLORIDE  +  glycine (Schotten-Baumann amide from acid)

Reactant  +  dimethyl sulfide (Corey-Kim oxidation of secondary alcohols)

Synthesis of Hippuric acid ›

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Hippuric acid

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