Weight | 182.175 g/mol |
---|---|
Formula | C9H10O4 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 2 |
Aromatic Rings | 1 |
Rotatable Bonds | 3 |
Homovanillic acid (306-08-1)
3 Methoxy 4 Hydroxyphenylacetic Acid · 4-Hydroxy-3-Methoxyphenylacetic Acid · 4 Hydroxy 3 Methoxyphenylacetic Acid
Score:
#128 in Neurology
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#577 in Neuroscience
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#2600 in Biology
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#3246 in Chemistry
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- On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method (Life Sciences, 1963)
- Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high-performance liquid chromatography with electrochemical detection. (Journal of Neurochemistry, 1982)
- Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients: Correlation With Psychosis and Response to Neuroleptic Treatment (Archives of General Psychiatry, 1986)
- Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography--electrochemical detection system. (Journal of Chromatography B: Biomedical Sciences and Applications, 1980)
- Regional rat brain levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid: concurrent fluorometric measurement and influence of drugs. (European Journal of Pharmacology, 1976)
- Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection (Analytical Biochemistry, 1983)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 3 Methoxy 4 Hydroxyphenylacetic Acid
- 4-Hydroxy-3-Methoxyphenylacetic Acid
- 4 Hydroxy 3 Methoxyphenylacetic Acid
- 3-Methoxy-4-Hydroxyphenylacetic Acid
-
SMILESCOC1=C(C=CC(=C1)CC(=O)O)O
-
InChIKeyQRMZSPFSDQBLIX-UHFFFAOYSA-N
- Pubchem - Homovanillic acid
- Wikipedia - homovanillic acid
Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine. Homovanillic acid is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. In psychiatry and neuroscience, brain and cerebrospinal fluid levels of HVA are measured as a marker of metabolic stress caused by 2-deoxy-D-glucose.
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Synthesis
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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