| Weight | 296.414 g/mol |
|---|---|
| Formula | C19H24N2O |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Imipramine N-oxide (6829-98-7)
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- Hepatic and extrahepatic metabolism of the psychotropic drugs, chlorpromazine, imipramine, and imipramine-N-oxide. (Naunyn-schmiedebergs Archives of Pharmacology, 1971)
- Metabolic interconversions between imipramine, its N-oxide, and its desmethyl derivative in rat tissues in vitro. (Biochemical and Biophysical Research Communications, 1968)
- Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine : preliminary application to oxidation pharmacogenetics (Therapeutic Drug Monitoring, 1993)
- Metabolic Interconversions and Binding of Imipramine, Imipramine-N-Oxide, and Desmethylimipramine in Rat Liver Slices (Xenobiotica, 1971)
- The kinetics of imipramine-N-oxide in man. (Pharmacology & Toxicology, 2009)
- The Teratogenic Effects of Thalidomide, Imipramine HCl and ImipramineNOxide HCl on White Danish Rabbits. (Pharmacology & Toxicology, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC[N+](C)(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)[O-]
-
InChIKeyQZIQORUGXBPDSU-UHFFFAOYSA-N
- Pubchem - Imipramine N-oxide
- Wikipedia - imipraminoxide
Imipraminoxide (brand names Imiprex, Elepsin), or imipramine N-oxide, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1960s for the treatment of depression. Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects. However, in clinical trials, imipraminoxide was found to have a faster onset of action, slightly higher efficacy, and fewer and less marked side effects, including diminished orthostatic hypotension and anticholinergic effects like dry mouth, sweating, dizziness, and fatigue.
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