| Weight | 321.163 g/mol |
|---|---|
| Formula | C15H10Cl2N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
lonidamine (50264-69-2)
AF 1890 · diclondazolic acid · 1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid
Score:
#1947 in Biochemistry
,
#4127 in Biology
,
#5205 in Chemistry
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- Sigma-Aldrich - lonidamine117.00 - 406.00 USD
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- Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. (Oncogene, 1999)
- Lonidamine, a Selective Inhibitor of Aerobic Glycolysis of Murine Tumor Cells (Journal of the National Cancer Institute, 1981)
- Effect of Lonidamine on the Energy Metabolism of Ehrlich Ascites Tumor Cells (Cancer Research, 1981)
- Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437. (Oncogene, 2001)
- Lonidamine: Efficacy and safety in clinical trials for the treatment of solid tumors (Drugs of Today, 2003)
- Development of EGFR-Targeted Polymer Blend Nanocarriers for Combination Paclitaxel/Lonidamine Delivery To Treat Multi-Drug Resistance in Human Breast and Ovarian Tumor Cells (Molecular Pharmaceutics, 2011)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - AF 1890
- diclondazolic acid
- 1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid
-
SMILESC1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O
-
InChIKeyWDRYRZXSPDWGEB-UHFFFAOYSA-N
- Pubchem - lonidamine
- Wikipedia - lonidamine
Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase.
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lonidamine
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