| Weight | 390.467 g/mol |
|---|---|
| Formula | C20H32F2O5 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 11 |
Lubiprostone (333963-40-9, 136790-76-6)
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- Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome results of two randomized, placebo-controlled studies (Alimentary Pharmacology & Therapeutics, 2009)
- Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Lubiprostone, a Locally-Acting Type-2 Chloride Channel Activator, in Patients With Chronic Constipation (The American Journal of Gastroenterology, 2008)
- Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers (American Journal of Physiology-gastrointestinal and Liver Physiology, 2006)
- Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation (Alimentary Pharmacology & Therapeutics, 2008)
- Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a doubleblind, placebocontrolled, doseranging study to evaluate efficacy and safety (Alimentary Pharmacology & Therapeutics, 2007)
- Efficacy and Safety of Lubiprostone in Patients with Chronic Constipation (Digestive Diseases and Sciences, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F
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InChIKeyWGFOBBZOWHGYQH-UHFFFAOYSA-N
- Pubchem - Lubiprostone
- Wikipedia - lubiprostone
Lubiprostone (rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006 and recommended for use in the by the National Institute for Health and Care Excellence (NICE) in 2014.
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Lubiprostone
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