| Weight | 352.471 g/mol |
|---|---|
| Formula | C20H32O5 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 12 |
prostaglandin h2 (42935-17-1)
Score:
#1261 in Biochemistry
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#3118 in Biology
,
#3900 in Chemistry
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- The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. (Nature, 1994)
- The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. (Journal of Biological Chemistry, 1990)
- The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase (Nature Structural & Molecular Biology, 1995)
- COMPARISON OF THE ACTIONS OF U46619, A PROSTAGLANDIN H2ANALOGUE, WITH THOSE OF PROSTAGLANDIN H2 AND THROMBOXANE A2 ON SOME ISOLATED SMOOTH MUSCLE PREPARATIONS (British Journal of Pharmacology, 1981)
- Prostaglandin H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. (Hypertension, 1990)
- High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H2 ReceptorMediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells (Diabetes, 2002)
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SMILESCCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)OO2)O
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InChIKeyYIBNHAJFJUQSRA-UHFFFAOYSA-N
- Pubchem - prostaglandin h2
- Wikipedia - Prostaglandin H2
Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme. It is acted upon by: Prostacyclin synthase to create prostacyclin Thromboxane-A synthase to create thromboxane A2 and 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) (see 12-Hydroxyheptadecatrienoic acid) Prostaglandin D2 synthase to create prostaglandin D2 Prostaglandin E synthase to create prostaglandin E2 It rearranges non-enzymatically to: A mixture of 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) and 12-(S)-hydroxy-5Z,8Z,10E-heptadecatrienoic acid (see 12-Hydroxyheptadecatrienoic acid) Use of Prostaglandin H2: regulating the constriction and dilation of blood vessels stimulating platelet aggregation Effects of Aspirin on Prostaglandin H2: Aspirin has been hypothesized to block the conversion of arachidonic acid to Prostaglandin
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